胃癌根治术后腹腔引流液癌胚抗原测定临床价值的初步探讨  

Clinical value of carcino-embryonic antigen assay after radical correction of gastric cancer

作　　者：董来荣 付斌 姚明 曹浩强 陈松劲 曹晨曦 毛宠珍 

机构地区：[1]嘉兴市第二医院肿瘤外科,浙江嘉兴314000

出　　处：《中华肿瘤防治杂志》2010年第16期1304-1306,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨胃癌D2根治术后腹腔引流液的癌胚抗原(CEA)水平变化对病情评估及预后判断的临床价值。方法:采用化学发光免疫分析法检测68例胃癌患者术d1、d3腹腔引流液CEA浓度,分析其与肿瘤浸润深度、淋巴结转移及病理分期的关系。结果:胃癌D2根治术后腹腔引流液CEA水平随肿瘤突破黏膜层、淋巴结转移、病理分期增加而上升(P<0.05),在T1、N0及Ⅰ、Ⅱ期患者中较低;当肿瘤突破黏膜层和(或)淋巴结转移后明显升高,P<0.05。结论:检测胃癌D2根治术后腹腔引流液CEA有助于病情估计及预后判断。OBJECTIVE：To approach the clinical value of the change of carcino-embryonic antigen （CEA） of celiac draining fluid in evaluating patient＇s condition and judging prognosis after D2-radical correction of gastric cancer.METHODS：The change of CEA level of the celiac draining fluid of 68 patients with gastric cancer were detected by chemiluminescent immunoassay （CLIA） on the 1st and 3rd day after surgery.The relationships between this change and the tumor infiltrating depth,regional lymph nodes metastasis and pathologic staging were analyzed.RESULTS：The increase of CEA level in celiac draining fluid after D2-radical correction of gastric cancer was correlated with the tumor breaking through mucosa and regional lymph nodes metastasis and pathology staging （P0.05）.The lower level of CEA was in the patients with T1,N0 and Stage Ⅰ/Ⅱ,and the higher level was in the patients with tumor breaking through mucosa and/or lymph nodes metastases presenting （P0.05）.CONCLUSION：It is useful to detect the level of CEA of celiac draining fluid after D2-radical correction of gastric cancer in evaluating patient’s condition and judging prognosis.

关 键 词：胃肿瘤/外科学 根治术 癌胚抗原 淋巴结切除术 

分 类 号：R735.2[医药卫生—肿瘤]