肿瘤相关性疲劳状况及其影响因素的相关性研究  

Status and influential factors of cancer-related fatigue

作　　者：刘楠楠[1] 陈晓秋[1] 于洪波[2] 王芬[1] 童刚领[1] 

机构地区：[1]北京大学深圳医院肿瘤科,广东深圳518036 [2]山东省肿瘤医院放疗科,山东济南250117

出　　处：《中华肿瘤防治杂志》2010年第16期1307-1310,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：广东省深圳市科技局计划项目(200903066)

摘　　要：目的:调查肿瘤患者疲劳状况并探讨其影响因素。方法:应用疲劳症状量表及一般状况登记表,对300例肿瘤相关性疲劳患者进行面对面问卷式调查,收集人口统计学特征、肿瘤及治疗相关信息、疲劳程度、持续时间及对生活质量影响等临床资料,采用SPSS13.0软件统计分析其影响因素。结果:性别、化疗次数、放疗、生物靶向治疗、内分泌治疗、白细胞减少和血小板减少对疲劳的影响无统计学意义,P>0.05;年龄、肿瘤分期、唑来膦酸对疲劳持续时间的影响有统计学意义,P<0.05;贫血对疲劳程度和生活质量的影响差异有统计学意义,P<0.05;正在化疗、肿瘤进展患者及有无规律体育锻炼对疲劳程度、对生活质量和疲劳持续时间的影响差异均有统计学意义,P<0.05。结论:肿瘤进展及正在化疗患者疲劳程度重,持续时间长,对生活影响明显。肿瘤分期、化疗、高龄、贫血和有无规律体育锻炼及特殊药物治疗均为肿瘤相关性疲劳的影响因素。OBJECTIVE：To investigate the status of fatigue in cancer patients and its affecting factors.METHODS：Totally 300 cancer-related fatigue patients were investigate by Fatigue Symptom Inventory,and demographic characteristic questionnaire and personal interview methods were used.The degree and duration of fatigue and the influence of life quality and the data of the tumor and related treatment were collected.The data analysis and influential factors were performed by variance analysis of SPSS 13.0 software.RESULTS：Gender,times of chemotherapy,radiotherapy,biological targeting therapy,endocrine therapy,leucopenia and thrombocytopenia were not significantly related to fatigue （P0.05）;age,cancer stage and zoledronic acid were significantly related to the duration of fatigue（P0.05）;anemia was significantly related to the degree of fatigue and the influence of life quality（P0.05）.The patients during the chemotherapy,tumor progression and regular exercise were significantly related to fatigue （P0.05）.CONCLUSIONS：The fatigue is significantly associated with chemotherapy and tumor progression.The stage of cancer,chemotherapy,advanced age,anemia,regular exercise and special medicine are all the influential factors of cancer-related fatigue.

关 键 词：肿瘤 相关性疲劳 影响因素 

分 类 号：R730.6[医药卫生—肿瘤]