炎症性肠病患者红细胞分布宽度与疾病活动性的关系  

Study on correlation between red cell distribution width and inflammatory bowel disease activity

作　　者：何淳[1] 郭野[2] 张麟[2] 陈倩[2] 吴卫[2] 黄春梅[2] 崔巍[2] 

机构地区：[1]北京大学口腔医院检验科,100081 [2]北京协和医院检验科

出　　处：《中华检验医学杂志》2010年第8期756-761,共6页Chinese Journal of Laboratory Medicine

摘　　要：目的 探讨IBD患者的RDW与疾病活动性的关系,评价RDW是否可以作为监测IBD活动性的指标.方法 选取IBD患者256例,分为2组：UC患者组：136例,包括活动期80例,缓解期56例;CD患者组：120例,包括活动期75例,缓解期45例;同时选取60例细菌性痢疾患者作为疾病对照组,选取门诊健康体检者80名作为健康对照组.利用Bayer Advia 2120全血细胞分析仪、IMMAGE800双光径免疫浊度分析仪、Vacuette全自动血沉分析仪分别检测各组患者和健康对照者的RDW、Hb、WBC、PLT、CRP、ESR、MCV等指标,判断疾病不同阶段RDW的变化趋势,同时分析RDW与CRP、ESR、PLT、Hb、MCV等指标的相关性.利用ROC曲线分析RDW鉴别IBD活动性的敏感度和特异度,验证其与IBD活动性的关系.结果 UC活动期组RDW值为（16.1±2.7）,UC缓解期组为（13.5±2.1）,疾病对照组为（13.0±2.0）,健康对照组为（12.8±1.8）,4组间RDW值差异有统计学意义（F=51.9,P＜0.01）,其中UC活动期组RDW值显著高于UC缓解期组、疾病对照组和健康对照组（t值分别为8.12、9.67、11.85,P均＜0.05）,UC缓解期组RDW值显著高于疾病对照组和健康对照组（t值分别为2.45、2.67,P均＜0.05）.CD活动期组RDW值为（16.9±2.2）,CD缓解期组为（13.8±1.1）,疾病对照组为（13.0±2.0）,健康对照组为（12.8±1.8）,4组间RDW值差异有统计学意义（F=113.9,P＜0.01）,其中CD活动期组RDW值显著高于CD缓解期组、疾病对照组和健康对照组（t值分别为11.47、18.63、18.72,P均＜0.05）,CD缓解期组RDW值显著高于疾病对照组和健康对照组（t值分别为3.60、3.72,P均＜0.05）.UC组和CD组RDW与CRP、ESR均呈正相关（r分别为0.484、0.525、0.286、0.358,P分别＜0.01、＜0.01、＜0.05、＜0.01）,与Hb、MCV呈负相关（r分别为-0.378、-0.271、-0.329,-0.298,P分别＜0.01、＜0.01、＜0.05、＜0.01）.在UC患者组中,与CRP、ESR、PLT、Hb、MCV相比,RDW的曲线下面积（0.854）最大Objective To investigate the correlation between RDW and disease activity in patients with IBD and evaluate clinical significance of RDW as a potential indicator to monitor IBD activity. Methods 256 patients with IBD were divided into two groups. One was UC group including 136 patients with 80 active period cases and 56 emission period cases. Another was CD group including 120 patients with 75 active period cases and 45 emission period cases. 60 bacillary dysentery diseases and 80 healthy controls were selected as bacillary dysentery group and healthy control group. RDW, Hb, WBC, PLT, CRP, ESR, MCV were tested and monitored with development of disease at different stages. We compared RDW with CRP,ESR, PLT, Hb, MCV parameters. By ROC curve analysis, the sensitivity and specificity of RDW was estimated in identifying the IBD＇s activity. Results The mean values of RDW in active UC group, remission UC group, bacillary dysentery group and control group were （ 16. 1 ± 2. 7）, （ 13.5 ± 2. 1 ）, （ 13.0 ± 2. 0）and （ 12. 8 ± 1.8）, respectively. There was significant difference among four groups （ F = 51.9, P 〈 0. 01 ）.RDW in active UC group was significant higher than that in remission UC group, bacillary dysentery group and healthy control group （ t = 8. 12, 9. 67, 11.85, P 〈 0.05） and RDW in remission UC group was significant higher than that in bacillary dysentery group and healthy control group as well （ t = 2. 45, 2. 67,P 〈0. 05）. The mean values of RDW in active CD group, remissive CD group,bacillary dysentery group and control group were （ 16. 9 ± 2. 2 ）, （ 13. 8 ± 1.1 ）, （ 13.0 ± 2. 0）, （ 12. 8 ± 1.8 ）. There was significant difference among four groups （ F = 113.9, P 〈 0. 01 ）. RDW in the active CD group was significant higher than that in remission CD group, bacillary dysentery group and healthy control group （t = 11.47,18.63,18. 72, P 〈 0. 05 ） and RDW in remission CD group was also significant higher than that in bacillary dysentery group and

关 键 词：炎性肠疾病 红细胞指数 Crobn病 结肠炎 溃疡性 

分 类 号：R574.62[医药卫生—消化系统]