7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸的合成  

Synthesis of 7-Substituted-2-amino-1,2,3,4-tetrahydro-2naphthalene Carboxylic Acid

作　　者：崔琳琳[1] 张群利[1,2] 米浩宇[1] 王恩思[1,3] 

机构地区：[1]吉林大学生命科学学院,长春130021 [2]东北林业大学包装工程系,哈尔滨150040 [3]吉林大学药学院,长春130021

出　　处：《吉林大学学报（理学版）》2010年第5期860-864,共5页Journal of Jilin University:Science Edition

摘　　要：以7-取代苯乙酸为原料,经由2-四氢萘酮中间体,海因水解为关键步骤合成7-取代-2-氨基-1,2,3,4-四氢-2-萘甲酸,总收率为32%,并考察了不同7-取代海因的水解条件.关键中间体及目标分子的结构经核磁共振氢谱、碳谱得到确认。7-Substituted-2-amino-1,2,3,4-tetrahydro-2-naphthalene carboxylic acid was synthesized through 2-tetralone intermediate by hydantoin hydrolysis from the starting materials 7-substituted phenylacetic acid in a total yield of 32%,and hydrolysis conditions of different 7-substituted hydantoin were examined.The structures of the key intermediate and the target molecule were confirmed by 1H NMR and 13C NMR.

关 键 词：7-取代-2-氨基-1 2 3 4-四氢-2-萘甲酸 合成 海因 水解 

分 类 号：O656.4[理学—分析化学]