疏肝导浊方药治疗非酒精性脂肪肝的临床研究  

Treating Non-alcohol Fatty Liver with Shugan Daozhuo Prescription

作　　者：王威[1] 李智[2] 陆怡[2] 江海涛[3] 张俊华 史红 胡利民 方文岩[5] 顾志敏[1] 杨林[1] 刘友刚[1] 王超[1] 田维[1] 

机构地区：[1]天津中医药大学,300193 [2]天津市和平区中医医院,300158 [3]天津中医药大学第二附属医院,300150 [4]天津市中医药研究中心,300022 [5]天津中医药大学第一附属医院,300193

出　　处：《天津中医药大学学报》2010年第3期123-125,共3页Journal of Tianjin University of Traditional Chinese Medicine

摘　　要：[目的]观察疏肝导浊方药对脂肪肝患者的临床症状、脂质代谢和肝、肾功能的影响。[方法]临床随机选取72例脂肪肝患者服用疏肝导浊方药3个月,服药前与服药后自身对照观察临床症状,进行药物有效率处理;服药前与服药后3个月的血糖(BG)、甘油三酯(TG)、胆固醇(TC)、谷丙转氨酶(ALT)、尿素氮(BUN)和肌酐(Cr)结果采用随机区组设计方差分析进行统计处理。[结果]疏肝导浊方药可以降低血清中BG、TG、TC和ALT的含量(P<0.01),对BUN和Cr的含量没有影响(P>0.05);服药前、后自身对照临床症状观察总有效率为67%。[结论]疏肝导浊方药可促进脂肪肝患者血糖血脂和ALT酶活性的降低,促进脂质代谢,恢复肝功能,治疗脂肪肝,并且在患者服药3个月中尚未发现肾脏损害。[Objective]To observe the effects of Shuogandaozhuo（Dispersing the stagnated liver QI and Reducing the turbid pathogen）medicine（SM）on patient with fatty liver,including clinic symptom,lipid metabolism and hepatic,nephric function.[Method]Seventy-two patient with fatty liver were randomly enrolled and treated with Shuogandaozhuo medicine for 3 months.Before and after treatment selfcomparisons were performed on the clinic symptom,BG,TG,TC,ALT,BUN,Cr.[Results]Shuogandaozhuo medicine could reduce the serum BG,TG,TC and ALT levels of patient with fatty liver（P 0.01）.No effect was found on the content of BUN,Cr levels.[Conclusion]SM can promote the reducing of blood glucose and lipid levels and serum ALT activity.

关 键 词：脂肪肝 疏肝导浊方药 胆固醇 甘油三酯 

分 类 号：R575.5[医药卫生—消化系统]