门冬氨酸鸟氨酸对恶性血液系统疾病化疗药物所致肝损害的防治效果分析  

The Control Efficiency of Ornithine Aspartrate on the Liver Function Damaged by Chemotherapy of Malignant Hematological Systemic Diseases

作　　者：吴冬梅[1] 朱桂华[1] WU Dong-mei,ZHU Gui-hua （Department of Hematology,People＇s Hospital of YUXI City,The Sixth Affiliated Hospital of Kunming Medical College,Yuxi 653100,China）

机构地区：[1]云南省玉溪市人民医院血液科,云南玉溪653100

出　　处：《医学信息》2010年第19期3572-3573,共2页Journal of Medical Information

摘　　要：目的探讨门冬氨酸鸟氨酸对恶性血液系统疾病化疗药物所致肝损害的防治作用。方法 111例患者分为单纯化疗组、化疗＋预防护肝组、化疗＋保肝治疗组,后2组在化疗同时给予每日静滴10g门冬氨酸鸟氨酸,治疗期间每周复查肝功能。结果各组肝功能损害发生率分别为22.64%、6.38%和18.18%,化疗加门冬氨酸鸟氨酸预防护肝组化疗后肝功能损害的发生率较单纯化疗组低（χ2=5.164,P〈0.05）。结论化疗同时应用门冬氨酸鸟氨酸护肝治疗可预防或减少化疗药物对肝脏的损害,加速肝功能恢复,保证治疗顺利完成。Objective To explore the control efficiency of Ornithine Aspartate （OA） on the Liver Function Damaged by Chemotherapy of Malignant hematological systemic diseases.Methods 111 cases of the patient were divided into the group of chemotherapy alone,the group of chemotherapy and prophylactic treatment with OA and the group of chemotherapy and treatment with OA,the interventional groups were treated with OA （10g per day venous instillation） during the chemotherapy,liver function were detected to evaluate the effect per week.Results The occurrence of liver function damage of the three groups were 22.64%,6.38% and 18.18%,respectively.Comparing the results of the group of chemotherapy and prophylactic treatment with OA with that of he group of chemotherapy alone,the occurrence of liver function damage was lower （χ2 =6.22,P =0.027 0.05）.Conclusion Ornithine Aspartate was effective in the prevention and treatment of the liver function damage caused by chemotherapy in patients of Malignant hematological systemic diseases,it may improve liver function and ensure the continuity of the treatment.

关 键 词：门冬氨酸鸟氨酸 恶性血液系统疾病 化疗 肝功能损害 

分 类 号：R747.9[医药卫生—神经病学与精神病学;医药卫生—临床医学]