南通市食管癌遗传流行病学研究  

AN EPIDEMIOLOGIC STUDY ON GENETIC FACTOR IN ESOPHAGEAL CANCER OF NAN-TONG

作　　者：栾婕[1] 孟蕾青[1] 王延青 蓝绍颖[2] 

机构地区：[1]青岛医学院第二附属医院绩效管理科,青岛266042 [2]南通大学公共卫生学院

出　　处：《现代预防医学》2010年第18期3407-3409,共3页Modern Preventive Medicine

摘　　要：[目的]探讨家族遗传因素在食管癌发生发展中的作用。[方法]调查分析食管癌病例组和对照组的一级亲属患食管癌的情况进行遗传流行病学研究。[结果]南通市食管癌具有家族聚集性,Li-Mantel-Gart法显示食管癌属于多基因遗传性疾病,分离比为0.183,(95%CI:0.156～0.210),遗传度为(82.8±19.2)%,存在家族聚集性,出生顺序分析显示南通食管癌的发生与出生顺序无关。[结论]遗传因素在南通食管癌的发病中占有重要地位,具有明显的家族聚集倾向。[Objective] To investigate the role of genetic factors on the occurrence of esophageal cancer.[Methods] The genetic epidemiologic study was performed to investigate the first degree relatives of esophageal cancer patients and controls.[Results] Esophageal cancer possessed the characteristics of familial aggregation in Nantong.The results of Li-Mantel-Gart＇s method showed that the genetic mode of esophageal cancer belonged to polygenetic disease,and segregation rate was 0.183,（95%CI：0.156-0.210）.The heritability of the first degree relatives was（82.8% ± 19.2%）.Results of Greenwood-Yule method showed that there was no significant difference between observed number and expected distribution of the birth orders.[Con-clusion] Genetic factor was an important factor in the occurrence of esophageal cancer.

关 键 词：食管癌 遗传流行病学 遗传度 

分 类 号：R735.1[医药卫生—肿瘤]