腺样囊性癌细胞SACC-83细胞对雪旺氏细胞趋化移动的影响  

The effect of salivary adenoid cystic carcinoma cell on the chemotactic migration of Schwann cell

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作  者:余立强[1] 薛红玉[1] 王平[2] 孙沫逸[3] 

机构地区:[1]解放军第309医院口腔科,主治医师北京100091 [2]北京军区政治部第四干休所门诊部,主治医师北京100036 [3]第四军医大学口腔医学院口腔颌面-头颈肿瘤外科,主任医师教授陕西710032

出  处:《中华老年口腔医学杂志》2010年第3期129-132,共4页Chinese Journal of Geriatric Dentistry

摘  要:目的:观察腺样囊性癌细胞在雪旺氏趋化移动中的作用,并探讨腺样囊性癌的嗜神经侵袭机制。方法:将雪旺氏细胞接种于Transwell小室上室,下室分别加入腺样囊性癌细胞、人舌癌细胞及成纤维细胞条件培养液,空白对照组下室中DMEM培养液无细胞条件培养液,于孵箱中孵育10h后计数移动到下室的雪旺氏细胞数。结果:与人舌癌细胞组、成纤维细胞组及空白对照组相比,腺样囊性癌细胞组中移动到下室的雪旺氏细胞数显著增加,而人舌癌细胞组、成纤维细胞组及空白对照组间移动到下室的雪旺氏细胞数无显著差别。结论:腺样囊性癌细胞产生的某种物质可促进雪旺氏细胞趋化移动,可能参与腺样囊性癌嗜神经侵袭机制。Objective:To observe the effect of salivary adenoid cystic carcinoma cell on the chemotactic migration of Schwann cell,and explore the neural invasion mechanisms of salivary adenoid cystic carcinoma.Methods:Schwann cell were seeded in the upper chamber of Transwell where the cell conditioned mediums of salivary adenoid cystic carcinoma,tongue cancer and fibroblast were placed in the low chamber respectively.There is no cell conditioned medium in the low chamber of blank control.The Schwann cell migrated into the low chambers were counted after 10 hour's incubation.Results:In contrast to tongue cancer group,fibroblast group and blank control group,the number of Schwann cell migrated into the low chamber in the salivary adenoid cystic carcinoma group increased sighificantly.The differences of the numbers of Schwann cell migrated into the low chambers among tongue cancer group,fibroblast group and blank control group are not significant.Conclusion:The substance produced by salivary adenoid cystic carcinoma cells promotes the chemotactic migration of the Schwann cell.It may be involved in the mechanisms of the perineural invasion in salivary adenoid cystic carcinoma.

关 键 词:腺样囊性癌 雪旺细胞 嗜神经侵袭 趋化 

分 类 号:R739.8[医药卫生—肿瘤]

 

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