乳腺癌中Ki67、Her-2和nm23的表达及其临床意义  

Expressions and the clinical significances of Ki67,Her-2 and nm23 in breast cancer

作　　者：赵鹰[1] 胡长军[1] 王鹏[1] 马斌林[2] 刘虎[1] 

机构地区：[1]新疆伊犁州友谊医院普外二科,835000 [2]新疆医科大学附属肿瘤医院

出　　处：《中国现代药物应用》2010年第18期18-19,共2页Chinese Journal of Modern Drug Application

摘　　要：目的研究Ki67、Her-2和nm23蛋白在乳腺癌组织中的表达,探讨其临床意义。方法应用免疫组化方法检测104例乳腺癌组织中Ki67、Her-2和nm23蛋白的表达水平。结果 Ki67、Her-2和nm23蛋白表达与乳腺癌淋巴结转移均密切相关。结论联合检测Ki67、Her-2和nm23蛋白表达是衡量乳腺癌预后的重要指标。Objective To study the expression of Ki67,Her-2 and nm23 protein in breast cancer,and the relation to biological behavior and prognosis.Methods The expression of Ki67,Her-2 and nm23 protein were determined by immunohistochemistry technique in 104 patients with gastric carcinoma.Results The expression levels of Ki67,HER-2 and nm23 protein were closely correlated with regional lymph node metastasis.Conclusion Combined analysis of Ki67,HER-2 and nm23 protein expression showed that were important indicator for judging the prognosis of breast cancer.

关 键 词：乳腺癌 KI67 HER-2 NM23基因蛋白 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]