肺癌病因研究中接尘量计算的真实性评价  

Verification of Exposure Assessment Used in a Nested\= Case\|Control Study of Lung Cancer

作　　者：陈卫红[1] 陈镜琼[1] 杨剑 

机构地区：[1]同济医科大学劳动卫生学教研室 [2]广西大厂矿务局卫生防疫站

出　　处：《工业卫生与职业病》1999年第3期134-137,共4页Industrial Health and Occupational Diseases

摘　　要：为评价肺癌病例对照研究中接尘剂量估算方法的真实性，对广西锡矿病因研究对象进行了重新计算。广西锡矿队列发现男性肺癌死者１３０例，配对照６２７例，共７５７人。其中接尘工人５７２名，发现各期矽肺共２４３例。根据历年工业卫生监测资料估算所有接尘工人的累积总粉尘接触量（ＥＣＴＤ），再计算不同接尘水平下矽肺的发病率。结果显示，随接尘水平上升，矽肺发病率升高，两者存在明显的接触剂量反应关系，完全符合矽肺发病特点。从而间接证实粉尘接触量计算是合理的。An indirect verification of a retrospective quantitative assessment of dust exposure used in a nested case\|control study of lung cancer among Guangxi tin miners was conducted.Cumulative total dust was calculated for each study subject based on historical industrial hygiene records.In this cohort,there were 130 male lung cancer cases and 627 controls.Among them there were 572 exposed miners and 243 of them were diagnosed as silicosis.A significant trend for exposure dose\|response relationship between the incidence of silicosis and cumulative total dust exposure was observed in silica exposed workers.The association between the dust exposure and incidence of silicosis suggested that calculation of cumulative total dust used in the case\|control study of lung cancer could accurately reflect the exposure dose\|response relation between silica or dust and lung cancer,if it existed.\;

关 键 词：接尘评价 接触剂量 反应关系 矽肺 肺癌 

分 类 号：R734.201[医药卫生—肿瘤]