食盐碘化状况下成人甲状腺疾病与碘摄入不足的相关性  

Impact of Salt Iodization on Adult Thyroid Disease and Its Relevance with Insufficient Iodine Intake

作　　者：陈彬[1] 吕肖锋[1] 姚璐[1] 

机构地区：[1]北京军区总医院内分泌科,北京100700

出　　处：《临床误诊误治》2010年第9期819-820,共2页Clinical Misdiagnosis & Mistherapy

摘　　要：目的调查研究目前食盐碘化状况下成人甲状腺疾病与碘摄入不足的相关性。方法随机选取于2007年1～6月在我院内分泌与代谢病专科门诊初诊的甲状腺疾病142例,进行人口资料学调查并测定甲状腺自身抗体以及尿碘物质量浓度。结果 142例经相关检查诊断为Graves病60例,慢性淋巴细胞性甲状腺炎(桥本病)40例,单纯性甲状腺肿25例,结节性甲状腺肿17例;男40例(28.2%),女102例(71.8%),男女构成比差异有统计学意义(χ2=27.07,P<0.01)。结节性甲状腺肿平均年龄均高于其他3种疾病,差异有统计学意义(F=60.30,P<0.01)。本组尿碘物质量浓度中位数227.45μg/L,≤50μg/L6例(4.2%),≥200μg/L93例(65.5%),不同疾病尿碘物质量浓度中位数比较差异无统计学意义(F=0.48,P>0.05)。甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)阳性率分别为54.2%与44.4%,TPOAb与TGAb有相关性(r=0.717,P<0.01);TGAb及TPOAb与尿碘物质量浓度无显著相关性(r=0.012,P>0.05)。结论在目前超足量的碘营养状况条件下,碘缺乏已不再是引起甲状腺疾病的主要原因。Objective To investigate the causes of adult thyroid disease and its relevance with insufficient iodine intake.Methods 142 out-patients primordially diagnosed as thyroid disease by Department of Endocrine and Metabolic Diseases in our hospital during January～June 2007 were randomly selected.All patients were investigated of population data and detected of thyroid autoantibody and sediment concentration of urinary iodine.Results Of the 142 patients,60 patients were diagnosed as Graves disease,40 patients were chronic lymphocytic thyroiditis（Hashimoto＇s disease）,25 patients were simple goiter,17 patients were nodular goiter.There were 40 males（28.2%）and 102 famales（71.8%）,the constitutes showed statistically significant difference（χ2=27.07,P0.01）.The average age of nodular goiter was higher than the other 3 kinds of diseases,the difference was statistically significant（F=60.30,P0.01）.The median urinary iodine sediment concentration was 227.45 μg /L：≤50 μg/L in 6 patients（4.2%） and ≥200 μg/L in 93 patients（65.5%）.There was no significant difference in median urinary iodine sediment concentration of different diseases（F=0.48,P0.05）.The positive rates of thyroid peroxidase antibody（TPOAb） and thyroglobulin antibody（TGAb） were 54.2% and 44.4% respectively,TPOAb was correlated with TGAb（r=0.717,P0.01）.There was no significant correlation of TGAb,TPOAb and urinary iodine sediment concentration（r=0.012,P0.05）.Conclusion In the current super-sufficient quantities of iodine nutrition conditions,iodine deficiency is no longer the main cause of thyroid disease.

关 键 词：甲状腺疾病 成年人 碘 尿液 物质量浓度 甲状腺自身抗体 相关性 

分 类 号：R151.3[医药卫生—营养与食品卫生学] R581[医药卫生—公共卫生与预防医学]