增殖性视网膜病变与血管新生的研究进展  

Advances in researches for the relationship between proliferative retinopathies and angiogenesis

作　　者：王海红[1] 沈伟[2] 王智[1] 

机构地区：[1]复旦大学附属金山医院眼科金山区眼病防治所,中国上海市200540 [2]复旦大学附属华山医院心内科,中国上海市200040

出　　处：《国际眼科杂志》2010年第10期1933-1936,共4页International Eye Science

基　　金：中国上海市卫生局科研基金资助项目(No.2009006)~~

摘　　要：增殖性视网膜病变,如增殖性糖尿病视网膜病变(proliferativediabeticretinopathy,PDR),早产儿视网膜病变(retinopathyof prematurity,ROP)等,是致盲的主要原因。这类疾病的病理特点是视网膜前血管过度生长,引发纤维瘢痕形成,最终导致视网膜脱离。这种不正常和不成比例的血管过度生成是一种代偿机制,用以克服早期阶段的微血管退化和恢复缺氧视网膜的代谢平衡。迄今为止,治疗方式很大程度上依赖于外科侵入性干预。在本篇综述中,我们以血管新生为中心,对这类疾病的发生机制和治疗策略进行深入讨论。Proliferative retinopathies such as proliferative diabetic retinopathy （PDR） and retinopathy of prematurity （ROP）, are the leading causes of blindness. These pathologies are characterized by excessive pre-retinal blood vessel growth that can ultimately lead to a fibrous scar formation and culminate in retinal detachment. This abnormal and disproportionate hyper-vascularization is a compensatory mechanism to overcome an earlier phase of microvessel degeneration and reinstate metabolic equilibrium to the hypoxic retina. To date, the treatment modalities to counter these diseases largely rely on invasive surgical interventions, In this review, tightly around the angiogenesis, we discuss the current views on mechanisms and available treatments and present future strategies to tackle these diseases.

关 键 词：视网膜 血管新生 氧中毒 代谢 炎症 

分 类 号：R774.1[医药卫生—眼科]