儿童松果体区非成熟性畸胎瘤的治疗策略(附20例报告)  

Treatment of pineal area non-mature teratomas in children (a report of 20 cases)

作　　者：宫剑[1] 马振宇[1] 张玉琪[1] 李春德[1] 吴明星[1] 甲戈[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,北京100050

出　　处：《中国临床神经外科杂志》2010年第9期524-527,共4页Chinese Journal of Clinical Neurosurgery

基　　金：北京市科技新星计划(2007B048);2008教育部优秀回国人员科研启动基金资助

摘　　要：目的为儿童松果体区非成熟性畸胎瘤的规范化治疗提供初步的经验和依据。方法回顾性分析2002～2008年收治的20例松果体区非成熟性畸胎瘤患者的临床资料。20例患者中,8例先行手术,术后辅助放、化疗;9例先行放疗,瘤体缩小后再行手术切除;3例仅行手术治疗。20例患者均进行追踪随访,并对疗效进行分析总结。结果 20例患者平均随访3年(2～6年)。综合治疗组17例(85%)未见肿瘤复发(最长6年);单纯手术组3例(15%),术后平均9个月后均因肿瘤复发死亡。结论根据我们初步的临床经验,提出非成熟性畸胎瘤的基本治疗原则,可获得较为满意的治疗效果。Objective To provide the preliminary experience and basis for standard treatment of pineal area non-mature terotomas in children.Methods The clinical data of 20 children with pineal area non-mature terotomas,who were treated in our hospital from 2002 to 2008,were analyzed retrospectively.Of 20 children with pineal area non-mature teratomas,8 received radiotherapy and chemotherapy after the neurosurgery,9 underwent neurosurgery after the terotomas were shrunk by radiotherapy,and 3 only underwent neurosurgery.All the children were followed up from 2 to 6 years （mean,3 years）.Results The following up showed that no terotomas recurred in 17 children receiving radiotherapy,chemotherapy and neurosurgery,3 only receiving neurosurgery died of the recurrence of the terotomas 9 months （mean） after the neurosurgery.Conclusions The curative effect of comprehensive treatment including neurosurgery,radiotherapy and chemotherapy on the pineal area non-mature terotomas in children is good,but the curative effect of only neurosurgery on them is bad.

关 键 词：非成熟性畸胎瘤 松果体区 儿童 治疗 

分 类 号：R739.41[医药卫生—肿瘤] R651.11[医药卫生—临床医学]