65例多原发癌的临床回顾性研究  

Retrospective investigation of 65 cases with multiple primary cancers

作　　者：朱莉菲[1] 薛鹏[1] 王理伟[1] 

机构地区：[1]上海交通大学附属第一人民医院肿瘤科,上海200080

出　　处：《复旦学报（医学版）》2010年第5期591-593,共3页Fudan University Journal of Medical Sciences

摘　　要：目的探讨多原发癌（multiple primary cancers,MPC）的发病特点、早期诊断、治疗和预后,以期提高对多原发癌的诊治水平。方法对我院1998年1月至2008年12月收治的65例MPC患者的临床资料进行回顾性分析。结果研究期间,在10 834例恶性肿瘤患者中发现MPC 65例,MPC的总体发生率为0.6%（65/10 834）。其中,双重癌发生率为0.4%（46/10 834）,三重癌发生率为0.1%（16/10 834）,四重癌发生率为0.02%（3/10 834）。发病间隔时间在3年以内者有13例,在3~5年者有22例,最长间隔时间为35年。首发癌和重复癌均以消化系统肿瘤最常见,其次是乳腺癌、泌尿生殖系统肿瘤及头颈部肿瘤。所有患者经病理学检查均为恶性肿瘤,经外科手术或放、化疗后的3年生存率为65%,5年生存率为40%。结论加强对MPC发病规律的认识,做到早期诊断、积极治疗,可延长生存期、改善预后。Objective To explore characteristics,early diagnosis,treatment and prognosis of multiple primary cancers（MPC） in order to promote its diagnosis and therapy. Methods Sixty-five MPC cases in our hospital from Jan.1998 to Dec.2008 were studied retrospectively. Results Sixty-five MPC cases were found in 10 834 cases with malignant tumors,and the incidence of MPC was 0.6%（65/10 834）,in which the incidences of duplex primary cancers,triple primary cancers and quadruple primary cancers were 0.4%（46/10 834）,0.1%（16/10 834） and 0.02%（3/10 834）,respectively.Thirteen cases had the interval no more than 3 years between the first occurrence and the recurrence,and 22 cases had the interval of 3-5 years.The longest interval was 35 years.Primary cancer and repetitive cancer occurred most frequently in digestive system with the next in breast,genitourinary system and head and neck.The 3-year and 5-year survival rate were 65% and 40%,respectively. Conclusions The mechanism and development of MPC should be researched further.Early diagnosis and active treatment can prolong the survival span and improve prognosis of MPC patients.

关 键 词：多原发癌 诊断 治疗 预后 

分 类 号：R73-31[医药卫生—肿瘤]