HuR VEGF和COX-2表达及临床病理因素与早期宫颈癌患者预后关系的分析  

Correlation among HuR, VEGF and COX-2 Expressions, Clinicopathologic Factors and Prognosis of Early (Stage-Ⅰ～Ⅱ) Cervical Cancer

作　　者：王敏[1] 彭宣荣[1] 朱彦丽[1] 史春雪[1] 史蕾[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳市110004

出　　处：《中国肿瘤临床》2010年第17期984-987,990,共5页Chinese Journal of Clinical Oncology

摘　　要：目的:分析和评价临床病理因素(年龄、临床分期、病理类型、组织学分级、癌灶大小、淋巴结转移)和生物学因素(HuR、VEGF及COX-2)与早期(Ⅰ～Ⅱ期)宫颈癌手术预后的关系。方法:采用免疫组化方法检测早期宫颈癌组织中HuR、VEGF及COX-2蛋白的表达,将可能与预后有关的因素进行单因素分析后再进行多因素分析。结果:癌灶大小、HuR蛋白阳性表达、COX-2蛋白阳性表达与预后相关(P均<0.05);临床分期、组织学分级、有无淋巴结转移、VEGF蛋白阳性表达与预后明显相关(P均≤0.01),不同年龄、病理类型与预后无关(P均>0.05)。组织学分级低者5年累计生存率显著低于组织学分级高者,前者死亡危险度是后者的2.948倍,是影响宫颈癌手术预后的第一位独立因素。其次为VEGF阳性表达,其相对危险度为2.801。结论:早期宫颈癌手术预后与临床分期、组织学分级、癌灶大小、有无淋巴结转移、HuR蛋白阳性、VEGF蛋白阳性、COX-2蛋白阳性有关,与年龄、病理类型无关。组织学分级、VEGF蛋白阳性是影响宫颈癌手术预后最显著的独立因素。Objective： To analyze and evaluate the correlation among the common clinico-pathologic characteristics such as age, clinical staging, pathological type, histological grading, tumor size, nodal metastasis; the biological factors such as HuR, VEGF and COX-2; and the prognosis of early （Stage Ⅰ-Ⅱ） cervical carcinoma. Methods- Immunohistochemical staining was used to detect the expression of HuR protein, VEGF protein and COX-2 protein in early （Stage Ⅰ-Ⅱ） cervical carcinoma. Univariate analysis of the factors that might be in relation to the prognosis of the early cancer patients was conducted. Based on these results, multi-variate analysis was then conducted using the COX proportional hazards regression model. Results： We found that tumor size and the expression of HuR and COX-2 proteins are all in relation to the prognosis of early （Stage Ⅰ-Ⅱ） cervical cancer （all P〈0.05）, and all clinical characteristics such as staging, histological grading, lymph node transmission and VEGF protein expression are significantly correlated with the prognosis of early （Stage Ⅰ-Ⅱ） cervical cancer （all P≤0.01）. Contrarily, age and pathological type are not in relation to the prognosis of early （Stage Ⅰ-Ⅱ） cervical cancer （/：）〉0.05）. The cumulative five-year survival rate was significantly lower in patients with low histological grades than in those with high histological grades. The risk of death of the former was 2.948 times higher compared to the latter. So, histological grading is the first independent factor that affects the prognosis of early cervical cancer. VEGF expression is the next independent factor, and the relative risk is 2.801. Conclusion： The prognosis of early （Stage Ⅰ-Ⅱ） cervical cancer is correlated with clinical staging, histological grading, tumor size, nodal metastasis, the HuR protein expression, and the VEGF and COX-2 protein expressions, but not correlated with age or pathological types. Histological grade and VEGF protein expression a

关 键 词：宫颈癌 临床病理和生物学因素 预后 

分 类 号：R737.33[医药卫生—肿瘤]