白细胞介素1受体辅助蛋白样2基因多态性与秦巴山区儿童认知能力相关性研究  

A study on the relationship between the polymorphisms in Interleukin 1 receptor accessory protein-like 2 and cognitive ability of the children in Qin-Ba mountainous region

作　　者：龚平原[1] 高晓彩[1] 贺波[1] 张科进[1] 郑子健[2] 黄绍平[3] 张富昌[1] 

机构地区：[1]西北大学生命科学学院,西安710069 [2]西北大学应用心理研究所,西安710069 [3]西安交通大学第二附属医院

出　　处：《中华行为医学与脑科学杂志》2010年第9期772-775,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金（30970967）;国家科技部重点基础科研“973”前期专项（2007CB516702）

摘　　要：目的 初步探讨白细胞介素1受体辅助蛋白样2（IL1RAPL2）基因多态性与有关认知能力的关系.方法 选择IL1RAPL2基因内的rs5962434、rs5916817、rs3764765和rs5962298等4个标记性SNP位点,使用PCR-SSCP方法进行基因分型,在陕南秦巴山区320名6～14岁儿童人群中分析这四个位点的多态性与一般认知能力以及韦氏智力量表中言语理解因子以及记忆/注意因子和知觉组织因子3个智商因子之间的相关性.结果 rs5962434、rs5916817、rs3764765和rs5962298位点在该人群中符合哈德-温伯格平衡（P＞0.05）,这4个标记位点的多态性与一般认知能力（P=0.81,0.53,0.79,0.90）、言语理解因子（P=0.58,0.47,0.69,0.87）、记忆/注意因子（P=0.69,0.35,0.76,0.90）均无显著相关性,与知觉组织因子在男女不同群体中也无显著相关性（P=0.70,0.85,0.76,0.90,0.65,0.22,0.98,0.90）.结论 本研究初步提示IL1RAPL2基因内有关位点的多态性可能与秦巴山区儿童的一般认知能力以及言语理解、知觉组织因子、记忆/注意因子等认知能力无明显关系.Objective To explore the relationship between interleukin 1 receptor accessory protein-like 2 （IL1RAPL2） gene and cognitive abilities of children in Qin-Ba mountainous region. Methods Four tagged SNPs （rs5962434,rs5916817, rs3764765 and rs5962298 ） in IL1RAPL2 were selected, and then genotyped by PCR-SSCP method in a 320 children sample aged from six to fourteen years old. Results The results showed the rs5962434, rs5916817 ,rs3764765 and rs5962298 had no deviations from Hardy-Weinberg equilibrium （P〉0.05）,and there were no significant statistical differences in the average psychometric scores of general cognitive ability（P=0.81,0.53,0.79,0.90） ,verbal comprehension （P=0.58,0.47,0.69,0.87 ） ,memory and concentration （P=0.69,0.35,0.76,0.90） among the compared genotype groups at each of the markers. Furthermore,the results also indicated that the four SNPs were not associated with perceptual organization in males and females respectively （P = 0.70,0.85,0.76,0.90,0.65,0.22,0.98,0.90 ）. Conclusion The present work suggests that the human general cognitive ability, the three cognitive factors of C-WISC scale are not influenced manifestly by the genetic variations in IL1RAPL2.

关 键 词：认知能力 智商因子 白细胞介素1受体辅助蛋白样2 多态性位点 

分 类 号：R749.1[医药卫生—神经病学与精神病学]