色氨酸羟化酶2基因多态性与反社会人格障碍及其冲动行为的关联研究  

Association analysis of tryptophan hydroxylase-2 gene polymorphism with antisocial personality disorder and impulsivity

作　　者：吴岩峰[1] 郑大同[1] 谭钊安[1] 柯晓燕[2] 张建平[1] 茆正洪[1] 曾彦英[1] 

机构地区：[1]南京医科大学第二附属医院,南京210011 [2]南京医科大学附属脑科医院,南京210011

出　　处：《中华行为医学与脑科学杂志》2010年第9期791-794,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：江苏省卫生厅科研项目（H200608）

摘　　要：目的 探讨色氨酸羟化酶2（Tryptophan Hydroxylase-2,TPH2）基因多态性与反社会人格障碍（Antisocial Personality Disorder,ASPD）及其冲动行为的关系.方法 选取TPH2基因启动子上游多态-703G/T（rs4570625）,采用PCR-RFLP基因分型技术测定117例反社会人格障碍患者和142名健康人的TPH2基因启动子上游多态-703G/T分布,运用Barratt冲动量表（BIS-11）评估其冲动行为.结果 ASPD组TPH2-703G/T基因型和等位基因频率分布和对照组间相比差异均有显著性（分别为x2=7.73,P＜0.05;x2=5.12,P＜0.05）.基因型GG和等位基因G与ASPD间存在显著正关联[分别为比数比（OR）=1.458,95%可信区间（95%CI）=1.080～1.968;OR=1.479,95% CI=1.045～2.094].ASPD患者GG、GT、TT三组基因型间BIS总分、注意因子、运动因子差异有显著性（P＜0.05）,而无计划因子差异无显著性.两两分析显示GG基因型组BIS-11总分及各因子分[分别为（71.28±7.50）分,（19.60±3.41）分,（25.73±4.92）分,（25.95±4.77）分]均高于GT基因型组[分别为（66.23±8.06）分,（17.79±3.02）分,（23.06±3.84）分,（25.38±4.97）分]和TT基因型组[分别为（66.55±8.49）分,（18.50±3.35）分,（23.45±4.08）分,（24.97±4.90）分],其中BIS-11总分、注意因子、运动因子差异有显著性（P＜0.05）.G等位基因组BIS-11总分及各因子分[分别为（69.38±8.04）分,（18.92±3.36）分,（24.73±4.69）分,（25.73±4.82）分]均高于T等位基因组[分别为（66.41±8.22）分,（17.98±3.26）分,（23.27±3.94）分,（25.15±4.89）分],其中BIS-11总分、注意因子、运动因子差异有显著性（P＜0.05）.结论 在中国汉族人群中TPH2-703G/T多态性可能与ASPD存在遗传关联,GG基因型和等位基因G可能与ASPD正关联,并且和冲动行为相关.Objective To study the association of tryptophan hydroxylase-2 （TPH2） gene polymorphism and antisocial personality disorder （ASPD） and its impulsivity in Chinese Han population. Methods The single nucleotide polymorphism （SNPs） of TPH2 in transcriptional control region,-703G/T,was analyzed by PCR-RFLP genotyping assay in 117 ASPD patients and 142 healthy controls. Barratt Impulsiveness Scale-11 （BIS-11） was used to evaluate the impulsivity of subjects. Results There were significant differences between ASPD and controis on genotype and allele frequencies of TPH2-703G/T （x2 = 7.73, P 〈 0.05; x2 = 5.12, P 〈 0.05）. The GG genotype and G allele were positively associated with ASPD（OR = 1.458,95% CI = 1.080 ～ 1.968 ;OR = 1.479,95% CI = 1.045 ～ 2.094）. The scores of BIS-11 and its factors in GG genotype group（（71.28 ± 7.50）, （19.60 ±3.41）, （25.73 ± 4.92）, （25.95 ± 4.77） ） were higher than GT genotype group （（ 66.23 ± 8.06）, （17.79 ±3.02） ,（23.06 ±3.84） ,（25.38 ±4.97）） and TT genotype group（（66.55 ±8.49）,（18.50 ±3.35）,（23.45 ±4.08）, （24.97 ± 4.90））, but only the difference of BIS-11 total scores, the attention and motor factor scores among three groups were statistically significant （P〈0.05）. The scores of BIS-11 and its factors in G allele group （（69.38 ±8.04）, （18.92 ± 3.36）, （24.73 ±4. 69）, （25.73 ±4.82）） were higher than T genotype group （（66.41 ±8.22）,（17.98 ±3.26）,（23.27 ±3.94）, （25.15 ±4.89））,however,only the difference of BIS-11 total scores, the attention and motor factor scores between two groups were statistically significant.Conclusion TPH2-703G/T polymorphism may be association with ASPD in Chinese Han population. The GG genotype and G allele may be the risk factors of ASPD and impulsivity.

关 键 词：反社会人格障碍 色氨酸羟化酶2 基因多态性 冲动行为 

分 类 号：R749.91[医药卫生—神经病学与精神病学]