ACE2-Ang(1-7)-Mas受体轴与肝纤维化  

ACE2-Ang(1-7)-Mas receptor axis and liver fibrosis

作　　者：王艳[1] 孙芳芳[1] 阴赪宏[1] 王宝恩[1] 

机构地区：[1]首都医科大学附属北京友谊医院感染暨急救医学科,北京100050

出　　处：《胃肠病学和肝病学杂志》2010年第9期777-779,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：中国肝炎防治基金会王宝恩肝纤维化研究基金(20090042)

摘　　要：肾素血管紧张素系统(renin angiotensin system,RAS)是人类生理功能的一个重要调节机制,在维持血压稳态、水盐平衡及局部组织器官的正常功能等方面具有重要作用。经典的RAS作用轴ACE-AngⅡ-AT1R在肝纤维化的发生过程中起促进作用,而ACE2-Ang(1-7)-Mas受体轴是新发现的RAS作用轴,是ACE-AngⅡ-ATR1的反向调节轴,对肝纤维化的发生具有保护作用。本文将ACE2-Ang(1-7)-Mas受体轴与肝纤维化关系的研究进展介绍如下。Renin-angiotensin system（RAS） is an important physiological regulatory mechanism,it plays an important role in maintaining blood pressure at steady state,maintaining local water and salt balance and the normal functions of tissues and organs.The role of the classical RAS axis ACE-AngⅡ-AT1R is considered to play a catalytic role in the process of liver fibrosis;ACE2-Ang（1-7）-Mas receptor axis is a newly discovered RAS axis,it appears to exert a counter-regulatory role in liver tissue with axis of ACE-Ang Ⅱ-ATR1 and plays a protective role in the process of liver fibrosis.We briefly review the relationship between ACE2-Ang（1-7）-Mas receptor axis and liver fibrosis in this article.

关 键 词：ACE2 Ang(1-7) MAS受体 肝纤维化 

分 类 号：R575[医药卫生—消化系统]