分化型甲状腺癌术后131↑I清甲效果的影响因素  

Influencing factors of radioiodine ablation of posts -urgical thyroid remnants in differentiated thyroid carcinoma

作　　者：董峰[1] 周荫保[1] 

机构地区：[1]天津医科大学总医院核医学科,300052

出　　处：《国际放射医学核医学杂志》2010年第1期27-31,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：利用131↑I清除甲状腺癌术后残留甲状腺组织（清甲）是分化型甲状腺癌（DTC）术后治疗中的重要步骤.清甲效果受诸多因素影响,包括口服131↑I的剂量、DTC的手术方式、术后甲状腺组织残留量、血清促甲状腺激素（TSH）与甲状腺球蛋白（Tg）水平、有无淋巴结及远处转移、手术距13I治疗时间的长短等.使用较大剂量131↑I进行清甲、采取甲状腺全切或近全切除术方式、131↑I治疗前较高水平的TSH,以及术后及时开始131↑I治疗等有助于提高清甲成功率.131↑I治疗前患者血清Tg水平偏高或存在转移灶,应适当加大131↑I治疗剂量.患者性别、年龄、病理类型等对清甲成功与否无明显影响.Radioiodine ablation of thyroid remnants after surgery is an important part of the treatment of differentiated thyroid carcinoma. The effect of ablation therapy is affected by many factors ,such as the administration dose of radioiodine, mode of operation, amount of thyroid remnants, the serum level of thyroidstimulating hormone and thyroglobulin, whether lymph nodes or distant metastasis are existed, the period of time between the ablation treatment and the operation and so on. Relative high dose of radioiodine,total or near-total thyroidectomy, high level of thyroid-stimulating hormone, ablation treatment onset after surgery without delay would contributed to the success of thyroid ablation. If the patient＇s thyroglobulin levels are high or metastasis foci are existed, the dose of radioiodine should increase to some extent. While patient＇s gender, age and pathology are unrelated to the treating effect.

关 键 词：甲状腺肿瘤 碘放射性同位素 外科手术 近距离放射疗法 

分 类 号：R736.1[医药卫生—肿瘤]