口腔白色念珠菌与龋病流行因素的相关性分析  

Correlation between Oral Candida Albicans and Dental Caries Epidemiology Factors

作　　者：赵英姿[1,2] 肖纯凌[3] 宫雁冰[1] 李菁华[2] 

机构地区：[1]沈阳市口腔医院牙体牙髓科,辽宁沈阳110002 [2]吉林大学白求恩医学院 [3]沈阳医学院

出　　处：《广东牙病防治》2010年第9期479-483,共5页Journal of Dental Prevention and Treatment

基　　金：辽宁省教育厅科学研究项目(2005240)

摘　　要：目的研究口腔白色念珠菌与龋病流行因素的关系。方法采集119名受检者的口腔牙菌斑,并记录其龋失补指数、年龄、性别、学历、吸烟、饮酒、义齿修复情况。聚合酶链反应法检测白色念珠菌、变形链球菌和发酵乳酸杆菌,计算其阳性率,分析其与龋病流行因素的关系。结果 34名受检者检出白色念珠菌阳性。白色念珠菌阳性者龋均为4.65,患龋率为79.4%(27/34);阴性者龋均为为3.60,患龋率为68.2%(58/85),白色念珠菌阳性与龋失补指数呈正相关(r=0.164,P=0.040)。白色念珠菌阳性者的变形链球菌检出率为47.1%(16/34),阴性者检出率为68.2%(58/85),差异有统计学意义,白色念珠菌阳性与变形链球菌检出率呈负相关(r=-0.197,P=0.032)。白色念珠菌阳性者中,变形链球菌阳性率高于乳酸杆菌阳性率,分别为47.1%(16/34)和14.7%(5/34),差异有统计学意义。白色念珠菌阳性与发酵乳酸杆菌、年龄、性别、学历、吸烟、饮酒、义齿均无显著相关(P>0.05)。结论口腔白色念珠菌可能为龋病的致病因素之一,与变形链球菌可能有拮抗作用。Objective To explore the relationship between oral Candida albicans and dental caries epidemiology factors. Methods One hundred and nineteen dental plaque samples were collected, while recording their age, gender, educational attainment, smoke, drink, DMFT/dmft, and denture. PCR method was preformed for identification Candida albicans, Streptococcus mutans, Lactobacillus fermentum, analyzing the correlation between oral Candida albicans and dental caries epidemiological factors. Results Thirty-four samples （34/119, 28.6%） were found to be Candida albicans carriers. The means of dmft/DMFT and the prevalence of dental caries were 4.65 and 79.4%（27/34） in Candida albicans carriers, and 3.60 and 68.2%（58/85） in non Candida albicans carriers. Candida albicans carriage was positively correlated with DMFT/dmft （r=0.164, P=0.040）. The presence of Streptococcus mutans in Candida albicans carriers （47.1%, 16/34） was significant lower than non-Candida albicans carriers （68.2%, 58/85）. Candida albicans carriage was negatively correlated with the presence of Streptococcus mutans （r=-0.197, P=0.032）. The presence of Streptococcus mutans （47.1%,16/34） was significant higher than that of Lactobacillus fermentum （14.7%,5/34） in Candida albicans carriers. No correlation was found between Candida albicans carriage and age, gender, educational attainment, smoke, drink, denture, and Lactobacillus fermentum detected （P0.05）. Conclusion Candida albicans maybe a putative cariogenic bacteria, and exhibited antagonistic action with Streptococcus mutans.

关 键 词：白色念珠菌 龋病 流行病学 变形链球菌 牙菌斑 

分 类 号：R781.1[医药卫生—口腔医学]