β-环糊精包覆碳纳米管基质用于氨基酸及小分子聚合物的MALDI-FT MS研究  

Carbon Nanotube-β-cyclodextrin Composites as Novel Matrix for Amino Acids and Small Molecular Polymer Analysis by MALDI-FT MS

作　　者：魏远隆[1,2,3] 周卫[4] 刘翻[1,2] 任志宇[4] 张凌怡[1] 杜一平[1] 郭寅龙[2] 

机构地区：[1]华东理工大学化学与分子工程学院,上海200237 [2]中国科学院上海有机化学研究所上海质谱中心,上海200032 [3]江西省出入境检验检疫局综合技术中心,南昌330002 [4]黑龙江大学功能无机材料化学省部共建教育部重点实验室,哈尔滨150080

出　　处：《高等学校化学学报》2010年第9期1729-1733,共5页Chemical Journal of Chinese Universities

基　　金：国家“九七三”计划项目(批准号:2007CB914104);国家科技支撑计划(批准号:2006BAK03A07);国家自然科学基金(批准号:20975039,20675083,20875097)资助

摘　　要：制备了可用作氨基酸及小分子聚合物的MALDI-FTMS分析基质的β-环糊精包覆多壁碳纳米管.通过引入β-环糊精改善其碳纳米管亲水性.所制备的β-环糊精包覆多壁碳纳米管的扫描电镜图表明,该碳纳米管呈现纳米带状结构.与通常的氧化碳纳米管相比,所制备的β-环糊精改性CNT具有更低的背景信号.进一步采用氨基酸及聚乙二醇等小分子化合物对所制备的碳纳米管进行评价,得到很强的氨基酸及聚乙二醇的碱金属离子加合峰,表明该材料可使小分子化合物解吸离子化,且背景干扰小不会影响到小分子化合物检测.由此可见,制备的β-环糊精包覆多壁碳纳米管适于小分子化合物的MALDI-MS分析.Hydrophilic carbon nanotube-β-cyclodextrin（ CNT-β-CD） composites were prepared as matrix by matrix assisted lasen desorption ionization-FT mass spectrum（ MALDI-FT MS） for the analysis of amino acids and small molecular polymer. The composites were characterized by SEM,and the results showed that the products presented randomly oriented quasi-nanobeltlike structures. Moreover,compared with the traditional oxidized carbon nanotubes,the CNT-β-CD presented a lower background in matrix assisted lasen desorption ionization-mass spectrum（ MALDI-MS） . The composites were also evaluated by amino acids and polyethylene glycol（ PEG） ,aiming at demonstrating the ability of desorption and ionization for samples. Intense signals corresponding to alkali cation adduct of amino acids and PEG were acquired,and they were independent of the background interference signals. Accordingly,CNT-β-CD is suitable for analysis of small molecules in MALDI-MS.

关 键 词：基质辅助激光解吸离子化 碳纳米管 Β-环糊精 小分子 

分 类 号：O657.63[理学—分析化学]