血管性痴呆的病理生理学机制和药物治疗  

Pathophysiological mechanisms and drug treatment of vascular dementia

作　　者：潘洁[1] 徐运[2] 

机构地区：[1]南京东南大学医学院,210009 [2]南京大学医学院附属鼓楼医院神经科,210008

出　　处：《国际脑血管病杂志》2010年第8期603-606,共4页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金（30470612）;江苏省科教兴卫工程医学重点人才项目（RC2007006）

摘　　要：缺血性脑损伤的级联反应可引起胆碱能神经功能障碍、炎症反应和氧化应激，在血管性痴呆的病理学过程中起重要作用。大量基础研究证实，胆碱酯酶抑制剂和N-甲基-D-天冬氨酸受体抑制剂能改善血管性痴呆患者的认知功能。然而，这些药物的疗效在临床试验中仅部分患者获得肯定，而且安全性和疗效均未达到预期，仍需进一步研究和探索。Cascade in cerebral ischemic injury may cause cholinergic dysfunction, inflammation and oxidative stress. It plays an important role in the pathological processes of vascular dementia. A large amount of basic research has confirmed that cholinesterase inhibitor and N-methyl-d-aspartate receptor inhibitor may improve cognitive function in patients with vascular dementia. However, the efficacy of these drugs has been confirmed in only a part of the patients, and their safety and efficiency have not achieved the expected results.Thus, it needs further study and exploration.

关 键 词：痴呆 血管性 乙酰胆碱酯酶 炎症 氧化性应激 胆碱酯酶抑制药 兴奋性氨基酸拮抗药 

分 类 号：R749.13[医药卫生—神经病学与精神病学]