卒中的氧化应激生物学标记物  

Biomarders of oxidative stress in stroke

作　　者：魏延[1] 沈新南[2] 

机构地区：[1]上海市青浦区疾病预防控制中心,210700 [2]复旦大学公共卫生学院营养与食品卫生学教研室,公共卫生安全教育部重点实验室,上海200032

出　　处：《国际脑血管病杂志》2010年第8期611-616,共6页International Journal of Cerebrovascular Diseases

摘　　要：氧化应激已被证实是脑损伤的重要机制之一。自由基是脑缺血再灌注和脑出血后最重要的产物之一，是评价2种类型卒中损伤的重要标记物。目前，一些相关的氧化应激生物学标记物，如脂质、DNA、蛋白质的过氧化产物，抗氧化酶、非酶性抗氧化小分子以及炎性和抗炎因子等日益受到重视。文章回顾和评价了卒中时的氧化应激生物学标记物。Oxidative stress has been demonstrated to be one of the important mechanisms for brain injury. Free radicals are one of the most important products following cerebral ischemia/reperfusion and intracerebral hemorrhage. They are the important markers for evaluating the 2 types of stroke injuries. At present, some relevant biomarkers of oxidative stress, such as lipid, DNA, protein peroxidation, antioxidant enzymes, and non-enzymatic antioxidant molecules as well as inflammatory and anti-inflammatory factors, are increasingly receiving attention. This article reviews and evaluates the biomarkers of oxidative stress in stroke.

关 键 词：卒中 氧化性应激 生物学标记物 活性氧 

分 类 号：R743.3[医药卫生—神经病学与精神病学]