Netrin-1及其受体在脑缺血中的作用  

The roles of netrin-1 and its receptors in brain ischemia

作　　者：龚琼[1] 余剑[1] 

机构地区：[1]中山大学附属第一医院神经内科,广州510080

出　　处：《国际脑血管病杂志》2010年第8期637-640,共4页International Journal of Cerebrovascular Diseases

摘　　要：以Netrin-1为代表的netrin家族是目前最受关注的轴突导向因子之一。在胚胎发育期，netrin-1通过吸引／排斥的双重机制对轴突生长和细胞迁移发挥导向作用。同时，netrin-1也在成年神经系统中广泛表达，并参与成年神经系统损伤后的结构和功能重塑。文章综述了netrin-1在缺血性脑损伤中的作用。The netrin family represented by netrin-1 is currently one of the most concerned axon guidance factors. Netrin-1 plays guidance roles for axon growth and cell migration by the dual mechanisms of attracting/excluding during the embryonic development. At the same time, netrin-1 also widely expresses in the adult nervous system and involves in the reconstruction of the structure and function after the adult nervous system injury, This article reviews the roles of netrin-1 in ischemic brain injury.

关 键 词：NETRIN-1 Netrin受体 神经生长因子类 脑缺血 细胞凋亡 

分 类 号：R743.3[医药卫生—神经病学与精神病学]