内皮素B受体基因甲基化与肿瘤关系的研究进展  

Advances in understanding the relationship between aberrant methylation of EDNRB and tumors

作　　者：吴川清[1] 陶凯雄[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院腔镜外科,湖北省武汉市430022

出　　处：《世界华人消化杂志》2010年第23期2448-2452,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30872473~~

摘　　要：遗传学修饰的DNA甲基化在肿瘤的发生发展中起重要作用.内皮素受体B(endothelin receptor B,EDNRB)基因是候选的抑癌基因之一.甲基化引起EDNRB基因失活与某些肿瘤发生的关系日益受到人们的关注,可能成为某些肿瘤早期诊断的分子标志物,同时由于DNA甲基化具有可逆性,也可为某些肿瘤提供新的治疗靶点.DNA methylation is a major epigenetic mechanism and plays an important role in the pathogenesis of tumors.The endothelin receptor B（EDNRB） gene is an important candidate tumor suppressor gene.EDNRB promoter hypermethylation has been detected in several types of tumors and may therefore be used as a useful molecular marker for tumor diagnosis.In addition,EDNRB gene methylation may also be used as a new target for tumor treatment due to the reversibility of DNA methylation.

关 键 词：内皮素受体B 基因 高甲基化 肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]