chemerin在克罗恩病患者血清中的水平及其临床意义  

Clinical signif icance of serum chemerin levels in patients with Crohn's disease

作　　者：顾頠[1] 庞智[1,2] 皇甫照[2] 华江[2] 周春立[1] 沈必武[1] 

机构地区：[1]江苏省苏州市立医院北区消化内科,江苏省苏州市215008 [2]苏州市消化系疾病与营养研究中心,江苏省苏州市215008

出　　处：《世界华人消化杂志》2010年第23期2483-2486,共4页World Chinese Journal of Digestology

摘　　要：目的:分析克罗恩病(Crohn's disease,CD)患者血清chemerin的浓度与性别、年龄和疾病活动指数的关系,探讨chemerin在CD中的临床意义.方法:选取CD患者50例与健康对照者50名作为研究对象,应用ELISA法检测两组对象血清chemerin的浓度,采用t检验比较两组间统计学差异.应用t检验、单因素方差分析及直线相关分析比较CD患者外周血中chemerin的浓度与性别、年龄和疾病活动指数的关系.结果:50例CD患者外周血中chemerin的浓度与50名健康对照者血清chemerin的浓度具有明显统计学差异,CD患者外周血中chemerin的浓度显著高于健康对照者(124.18μg/L±21.32μg/Lvs95.38μg/L±11.22μg/L,P<0.01).CD患者血清chemerin浓度与疾病活动指数间存在显著的正相关(r=0.438,P<0.05),而与性别和年龄间均不存在显著的相关关系(P>0.05).结论:CD患者chemerin水平明显升高,与疾病活动指数间存在显著的正相关.AIM：To analyze the clinical significance of serum chemerin levels in patients with Crohn＇s disease（CD） by evaluating the correlation of serum chemerin with gender,age and CD activity index（CDAI）.METHODS：Serum samples were collected from 50 CD patients and 50 healthy controls to determine chemerin levels by enzyme-linked immunosorbent assay（ELISA）.The t-test was used to compare the statistic difference in serum chemerin levels between the two groups.The correlation of serum chemerin with gender,age and CDAI were analyzed by the test,one-way analysis of variance,and Pearson＇s correlation.RESULTS：Serum chemerin level was significantly higher in CD patients than in healthy controls（124.18 μg/L ± 21.32 μg/L vs 95.38 μg/L ± 11.22 μg/L,P 0.01）.There was a significant positive correlation between serum chemerin level and CDAI（r = 0.438,P 0.05） though no correlation was noted between serum chemerin level and gender or age in CD patients（both P 0.05）.CONCLUSION：These findings indicate that the potential regulatory function of chemerin in intestinal inflammation may be associated with the immunopathogenesis of CD.

关 键 词：CHEMERIN 克罗恩病 酶联免疫吸附试验 

分 类 号：R363[医药卫生—病理学]