正常成人听觉诱发电位P50的年龄和性别差异  

Age and gender difference in auditory evoked potential P50 in normal adults

作　　者：谭淑平[1] 邹义壮[1] 杨甫德[1] 李详红[1] 王健[1] 王东 张进国[1] 李东[1] 周东丰[2] 

机构地区：[1]北京回龙观医院,北京100096 [2]北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191 [3]山东省威海经区医院,山东威海264200

出　　处：《中国心理卫生杂志》2010年第10期762-766,共5页Chinese Mental Health Journal

基　　金：北京市科委2006年重大科研资助(D0906001000091);北京市优秀人才基金(2007id0301400101)

摘　　要：目的:研究正常人听觉诱发电位P50特征以及年龄、性别因素的影响。方法:从北京回龙观医院职工以及附近小区居民中选取153例健康被试,按年龄分为两组,年龄1组(<50岁)86人(男40人,女46人),年龄2组(≥50岁)67人(男26人,女41人)。使用脑电生理记录仪,采用条件刺激(S1)-测试刺激(S2)模式进行听觉诱发电位P50检测。结果:(1)年龄2组S2波幅高于年龄1组,但仅两组女性被试间的差异具有统计学意义[(2.44±1.68)μV vs.(1.15±1.09)μV,P<0.01]。(2)年龄2组S1-S2值小于年龄1组,但仅两组男性被试间的差异具有统计学意义[(1.80±0.94)μV vs.(2.73±1.93)μV,P<0.05]。(3)年龄2组门控比(S2/S1)高于年龄1组,两组女性被试间差异具有统计学意义[(58.17±42.06)vs.(31.52±31.60),P<0.01],两组男性被试间有类似趋势[(41.00±31.88)vs.(25.78±36.28),P=0.09]。(4)方差分析显示,年龄和性别对S2波幅均有显著效应(P<0.01),且存在交互作用(P<0.05),年龄对门控比(S2/S1)有显著效应(P<0.01);(5)相关分析显示,女性被试年龄与门控比呈正相关(r=0.30,P<0.01),男性被试年龄与门控比无统计学意义相关(P>0.05)。结论:正常人听觉诱发电位P50指标存在性别和年龄差别,50岁以上可能存在听觉门控功能减弱,尤以女性为著。Objective： To observe the characteristics of auditory evoked potential P50 in normal controls and effects of gender and age. Methods： Auditory evoked potentials P50 were recorded in 153 normal controls [ （ divided into age group Ⅰ （ younger than 50 ） and age group Ⅱ （ older than 50 ） ] by conditioning （ S1 ） -testing （ S2 ） paradigm presented with auditory double clicks, using a 64 channels ERP instrument. Results： （ 1 ） Age group Ⅱ demonstrated lager S2 amplitudes than age group Ⅰ. But only in female subjects, the difference of S2 amplitudes between two age groups [ （2.44±1.68） μV vs. （ 1.15 ±1.09 ） μV, P 〈 0. 01 ） ] was statistically significant. （2） Age group Ⅱ demonstrated smaller S1-S2 amplitude than age group Ⅰ. But only in male subjects, there was a significant difference of S1-S2 amplitudes between two age groups [ （ 1.80±0. 94） μV vs. （2. 73 ± 1.93）μV, P 〈0. 05） ] . （3） Age group Ⅱ demonstrated higher S2/S1 ratio than age group Ⅰ. In female subjects, the difference of S2/S1 ration between two age groups [ （ 58. 17 ± 42.06 ） vs. （ 31.52 ± 31.60）, P 〈 0. 01 ） ] was statisti-cally significant. In male subjects, there was a similar difference of S2/S1 ratio between two age groups [ {41.00 ±31.88 ）vs. （ 25.78 ± 36. 28 ）, P = 0. 09 ）] . （ 4 ）There were significant main effects and interactive effects of age and gender on S2 amplitudes （ P 〈 0. 01 ） . A significant main effect of age on S2/S1 ratio exhibited （ P 〈 0. 01 ） . （ 5） There was a significant positive correlation between age and S2/S1 ratio in female subjects （r = 0. 30, P 〈 0.01 ） . No similar correlation between age and S2/S1 ratio demonstrated in male subjects. Conclusion： Auditory can evoke potential P50 affected by gender and age in normal subjects. Auditory gating of people elder than 50 maybe become weaker, especially in females.

关 键 词：感觉门控 听觉诱发电位 性别 PSO 

分 类 号：R741.044[医药卫生—神经病学与精神病学]