根治幽门螺杆菌感染治疗疗效观察与护理  

Observation and nursing of eradication of Helicobacter pylori infection

作　　者：王芬娟[1] 王欣[1] 葛维媛[1] 

机构地区：[1]山东省青岛市市立医院,山东青岛266071

出　　处：《中国医药导报》2010年第28期30-31,共2页China Medical Herald

摘　　要：目的:探讨三组用药方案根治幽门螺杆菌(Hp)感染临床疗效的观察与护理。方法:396例经胃镜检查确认为慢性胃炎和消化性溃疡Hp阳性患者,随机分为三组。1组:奥美拉唑20mg+克拉霉素500mg+阿莫西林1000mg,po,bid;2组:奥美拉唑20mg+阿莫西林1000mg+甲硝唑400mg,po,bid;3组:奥美拉唑20mg+阿莫西林1000mg+呋喃唑酮100mg,po,bid。每组132例,均以7d为1个疗程,用药后,7d内分别做门诊和电话随访,记录服药后有无不良反应发生。结果:三组Hp根除率:1组为86.12%;2组为59.23%;3组为92.24%,1组和3组比较,无显著性差异(χ2=2.70,P>0.05);2组和1组比较,有非常显著性差异(χ2=39.51,P<0.01),3组>1组>2组。结论:三联疗法有根除Hp作用,无不良反应发生。Objective： To observe the three drug regimens eradication of Helicobacter pylori （Hp） infection therapy. Methods： 396 confirmed by endoscopy for chronic gastritis and peptic ulcer Hp-positive patients were randomly divided into three groups. Group 1, Omeprazole 20 mg＋Clarithromycin 500 mg＋Amoxicillin 1 000 mg, po, bid; group 2, Omeprazole 20 mg＋ Amoxicillin 1 000 mg＋Etronidazole 400 mg, po, bid; group 3, Omeprazole 20 mg＋Amoxicillin 1 000 mg＋Furazolidone 100 mg, po, bid. 132 cases in each group, there was a course of 7 days after treatment, were done within 7 days of outpatient and telephone follow-up, record adverse reaction after taking place. Results： Three groups of Hp eradication rates as, group 1 of 86.12%; group 2 of 59.23%; group 3 of 92.24%, there was no significant difference between group 1 and 3 （χ2=2.70, P0.05）, there was a significant difference between group 1 and 2 （χ2=39.51,P0.01）, group 3group 1group 2. Conclusion： A triple therapy method could have the role of Helicobacter pylori infection and no adverse reaction.

关 键 词：幽门螺杆菌 慢性胃炎 消化性溃疡 护理 

分 类 号：R573[医药卫生—消化系统]