4-去甲氧基柔红霉素治疗急性白血病9例临床分析  

A clinical analysis of idarubicin treatment of acute leukemia

作　　者：张涛[1] 许敏华[1] 祁明芳[1] 

机构地区：[1]暨南大学医学院第一附属医院血液科,广东广州510630

出　　处：《暨南大学学报（自然科学与医学版）》1999年第4期45-47,共3页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的：为了观察以４ － 去甲氧基柔红霉素（ Ｉ Ｄ Ａ） 为主的化疗方案治疗急性白血病的疗效。方法：采用 Ｉ Ａ 和 Ｉ Ｅ 方案治疗９ 例急性白血病（ 初治４ 例，复发或难治５ 例） ，其中急性淋巴细胞白血病２ 例，急性非淋巴细胞白血病７ 例，观察血像、骨髓像、肝肾功能、心肌酶等项目。结果：５ 例患者（ 初治３ 例，复发或难治２ 例） 一疗程达完全缓解，有效率为５５５ ％ ，８ 例出现较严重的骨髓抑制，白细胞最低值平均为（１４５ ±１６７） ×１０９／ Ｌ，中性粒细胞＜ ０ ．５ ×１０９／ Ｌ 者占８５６７ ％ ，持续５ ～４３ ｄ ，血小板最低值平均为（４００７ ±２２９８） ×１０９／ Ｌ，６ 例出现感染，５ 例体温＞ ３８５ ℃，持续３ ～２３ ｄ 。结论：４ － 去甲氧基柔红霉素治疗急性白血病有效率５５５ ％ ，除骨髓抑制外，其他毒副反应轻微，在骨髓抑制期。Aim:To evaluate the effectiveness of chemotherapeutic regiment consisting mainly of idarubicin in the treatment of patients with acute leukemia. Methods:Total 9 patients were included in the study. Among these patients, 2 were with acute lymphoblastic leukemia, the remaining was with non-lymphoblastic leukemia, and 5 of them had refractory or relapsed.Results:The result showed that 5 patients achieved complete remission (CR) after one course of chemotherapy, the CR rate was 55.5%. Severe bone marrow suppression occurred in 8 patients. The average nadir count of WBC and platelet was (1.45±1.67)×10 9/L, (40.07±22.98)×10 9/L respectively. The patients whose absolute neutrophil count once lowered to 0.5×10 9/L were 85.67% and last 5-43 days. Infections occurred in 6 patients. And the temperature in 5 patients was higher than 38.5℃ which persisted for 3～23 days. Other side effects were mild. Conclusions: This chemotherapy regiment appears to be effective in the treatment of acute leukemia.

关 键 词：急性白血病 IDA 化疗 治疗 临床分析 

分 类 号：R733.710.5[医药卫生—肿瘤] R979.1[医药卫生—临床医学]