黄连素降糖作用机制的研究进展  

The progress of hypoglycemic mechanism of berberine

作　　者：张日东[1] 魏敬[1] 

机构地区：[1]南京医科大学附属南京第一医院内分泌科,江苏南京210006

出　　处：《现代生物医学进展》2010年第17期3350-3352,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(30271527)

摘　　要：黄连素是从毛莨科黄连属植物黄连、云连、黄柏等含小檗碱植物药中提取的生物碱,也可以人工合成。其作为抗感染药已有数十年的应用历史和经验。近十年广泛的研究发现其具有降血糖、降血脂、抗心律失常、抗癌、抗血小板聚集、增强机体免疫功能等作用,其中降血糖报道日渐增多。目前认为可能的机制主要与:增加胰岛素敏感性改善胰岛素抵抗;促进胰岛β细胞再生及功能恢复;抑制蔗糖酶、麦芽糖酶等二糖酶活力,减少葡萄糖吸收等相关。本文对近年来黄连素的降血糖临床疗效及可能的机制作一综述。Berberine is a coptis that comes from cork and other herbal extracts containing berberine alkaloid,it also can be synthesized.Berberine has been applied as anti-infective drugs for several years.People found that berberine can reduce fasting serum glucose,blood fat,anti-arrhythmia,anti-cancer,anti-platelet aggregation and enhance immunological function and so on in recent yesrs,but the hypoglycemia effects are reperted widely now.The possible main mechanism contains increase the sensitivity of insulin and decreae the insulin resistance;promoteβ-cell regeneration and functional recovery;suppress the activy of sucrase and maltases,and reduce glucose uptake.This review contains the hypoglycemic efficacy and possible mechanisms of berberine.

关 键 词：黄连素 2型糖尿病 降血糖 

分 类 号：R451[医药卫生—治疗学]