厌氧菌在肿瘤基因治疗中的研究进展  

Research progress on anaerobic bacteria in tuomr gene therapy

作　　者：王立英(综述)[1] 任瑞美(综述)[1] 于金明(审校)[1] 

机构地区：[1]山东省肿瘤医院内六科,济南250017

出　　处：《国际肿瘤学杂志》2010年第9期665-667,共3页Journal of International Oncology

摘　　要：实体瘤乏氧代谢区的存在，降低了放化疗的治疗效果，成为肿瘤治疗中难以逾越的障碍。基因治疗是肿瘤治疗中最有前途的方法，但目前所使用的基因转移载体的靶向性较差，而厌氧菌具有趋低氧的特点，对实体瘤组织具有良好的靶向性，成为肿瘤基因治疗的转移载体。Hypoxic metabolism in solid tumor reduces chemoradiotherapy effect and become the obstacle in tumor therapy. Gene therapy is the most promising tumor treatment method, but currently using carriers cannot target tumors accurately. Anaerobic bacteria has become the transferring carrier in tumor gene therapy because it has tendency to hypoxia in solid tumors and can target solid tumors more accurately.

关 键 词：肿瘤 细菌 厌氧 基因疗法 

分 类 号：R394[医药卫生—医学遗传学]