MHV-3诱导暴发型肝衰竭小鼠肝组织细胞因子表达的变化  

The chang es of serum and hepatic cytokines in MHV-3-induced fulminant hepatic failure in mice

作　　者：陈韬[1] 朱琳[1] 邹勇[2] 宁琴[1] 

机构地区：[1]华中科技大学附属同济医院感染性疾病研究所/感染病科,武汉市430030 [2]广州市中山大学附属第三医院输血科

出　　处：《实用肝脏病杂志》2010年第5期323-324,共2页Journal of Practical Hepatology

基　　金：国家973计划传染病基础研究重大专项(编号:2007CB51290)

摘　　要：目的研究病毒感染所致急性肝衰竭小鼠细胞因子的变化。方法利用MHV-3病毒诱导Balb/cJ小鼠暴发型肝炎模型;采用ELISA法测定外周血和肝脏IFN-γ和TNF-α水平。结果随着MHV-3感染时间的延长,动物外周血和肝组织IFN-γ和TNF-α水平逐渐增高,在小鼠死亡时达到高峰。结论 IFN-γ和TNF-α可能参与了MHV-3诱导的暴发型肝炎肝脏损伤的发病过程。Objective To investigate the levels of IFN-γ and TNF-α in MHV-3-induced fulminant hepatic failure.Method MHV-3-induced fulminant hepatic failure was adopted in mice and the serum and hepatic levels of IFN-γ and TNF-α was assayed by ELISA.Results As MHV-3 infection passed by,the serum and hepatic levels of IFN-γ and TNF-αwas elevated significantly,and they reached the highest before the mice were dead.Conclusion IFN-γ and TNF-αmight take part in the pathogenesis of MHV-3-induced fulminant hepatic failure in mice.

关 键 词：暴发型肝炎 MHV-3 细胞因子 

分 类 号：R575.3[医药卫生—消化系统]