γ-分泌酶组件蛋白Nicastrin的研究进展  

Progress in the research on Nicastrin,one of essential subunits of γ–secretase

作　　者：龙志敏[1] 贺桂琼[1] 

机构地区：[1]重庆医科大学神经科学研究中心,人体解剖教研室,重庆400016

出　　处：《生命科学》2010年第9期906-912,共7页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30700885);教育部重点项目资助计划(209102);重庆市教委科学技术研究项目(KJ090328);重庆市首批高等学校优秀人才资助计划(渝教人[2009]2号)

摘　　要：Nicastrin(NCT)是高度糖基化的I型跨膜蛋白,是γ-分泌酶复合物的重要组件蛋白之一,广泛分布于人类或鼠的所有细胞类型。它不仅与γ-分泌酶的组装和成熟密切相关,其构象及表达变化对γ-分泌酶活性和阿尔茨海默病(Alzheimer's disease,AD)中β淀粉样蛋白(amyloid proteinβ,Aβ)的产生及降解也起重要调节作用。本文就国际上近几年在NCT的结构、合成、分布、降解及功能等方面的研究进展作一综述。Nicastrin（NCT） ,one of the most important components of γ-secretase,is a highly glycosylated type I transmembrane glycoprotein. It is expressed in almost all cell types in human and mouse. NCT is not only closely related to the assembly and maturation of γ-secretase complex,more importantly,changes of its conformation and expression have a significant effect on the regulation of γ-secretase activity,as well as the generation and degradation of amyloid β peptide in Alzheimer＇s disease. This review summarizes the development of structure,synthesis,distribution,degradation and function of NCT in recent years,including that in our laboratory.

关 键 词：NICASTRIN Γ-分泌酶 Β淀粉样蛋白 阿尔茨海默病 

分 类 号：R745.7[医药卫生—神经病学与精神病学] R322.85[医药卫生—临床医学]