抗类脂A治疗梗阻性黄疸病人血液IL-6、IL-8水平的影响  

Changes of plasma IL 6 and IL 8 level during anti endotoxin treatment in patients with obstructive jaundice

作　　者：李智华[1] 韩本立[1] 何振平[1] 李昆[1] 秦孝健[1] 

机构地区：[1]第三军医大学附属西南医院肝胆外科中心

出　　处：《第三军医大学学报》1999年第4期265-267,共3页Journal of Third Military Medical University

摘　　要：目的：观察梗阻性黄疸病人术前抗内毒素治疗对内毒素血症抑制及ＩＬ－６、ＩＬ－８的影响。方法：梗阻性黄疸病人分３组在术前分别给予一般手术治疗（ＯＪ组），口服胆盐（ＯＪＴ１组）和静脉注射抗内毒素抗体（ＯＪＴ２组）观察血浆内毒素（ＥＴ）、ＩＬ－６及ＩＬ－８含量变化。结果：３组术前ＥＴ、ＩＬ－６和ＩＬ－８水平差异不显著。ＯＪＴ１组和ＯＪＴ２组用药后血浆ＥＴ水平均显著下降，明显低于ＯＪ组（Ｐ＜０．０１），术后进一步降低。ＩＬ－６在术后１４ｄ显著降低（Ｐ＜０．０１），ＩＬ－８在术后７ｄ降低（Ｐ＜０．０５）。结论：术前应用胆盐和抗内毒素抗体可有效降低梗阻性黄疸病人围手术期血浆ＥＴ、ＩＬ－６及ＩＬ－８水平。Objective: To investigate the changes of plasma IL 6 and IL 8 level and the inhibitory effects of preoperative administraction of bile salt or anti endotoxin antibody against endotoxemia in cases of obstructuve jaundice. Methods: The patients with obstructive jaundice were randomized into OJT1 group taking bile salt orally, OJT2 group receiving intravenous anti endotoxin antibody and OJ group receiving general treatment. The plasma level of endotoxin (ET), IL 6 and IL 8 were determined in all the cases. Results: The plasma ET level was significantly lower in the patients of OJT1 and OJT2 groups than in those of OJ group preoperatively and was further decreased postoperatively ( P <0.01). The plasma IL 6 and IL 8 levels were significantly lower on the 7th to 14th day postoperatively in the OJT1 and OJT2 groups than the preoperative levels ( P <0.05 and P <0.01). Conclusion: Preoperative administration of oral bile salt and intravenous anti ET antibody could efficiently decrease the plasma levels of ET, IL 6 and IL 8 pre and postoperatively in cases of obstructive jaundice.

关 键 词：梗阻性黄疸 围手术期 白细胞介素 抗类脂A 

分 类 号：R575[医药卫生—消化系统] R657.4[医药卫生—内科学]