炔基锌与醛的催化不对称加成反应研究进展  

Progress on Catalytic Asymmetric Addition of Alkynylzinc Reagents to Aldehydes

作　　者：李高伟[1] 王晓娟[2] 赵文献[1] 郭保国[1] 郑昕[1] 王敏灿[2] 

机构地区：[1]商丘师范学院化学系有机新材料合成重点实验室,商丘476000 [2]郑州大学化学系河南省化学生物与有机化学重点实验室,郑州450052

出　　处：《有机化学》2010年第9期1292-1304,共13页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20672102;20972091)资助项目

摘　　要：光学活性的炔丙醇是一类很重要的手性合成砌块,而末端炔对醛的不对称亲核加成是合成手性二级炔丙醇非常有效的方法.以手性配体的结构类型为依据,综述了炔基锌试剂对醛的不对称加成反应的研究进展.Optically active propargylic alcohols are important and versatile building blocks in asymmetric synthesis. The direct enantioselective addition of terminal alkynes to aldehydes is a very effective way in the synthesis of chiral secondary propargylic alcohols and has gained considerable significance. Research developments in the asymmetric addition of zinc alkynylides to aldehydes are reviewed according to different structure types of chiral ligands.

关 键 词：不对称合成 醛 炔丙醇 炔基化 

分 类 号：O643.32[理学—物理化学]