蒙特利尔认知评估量表用于帕金森病认知评估的可行性研究  

Feasibility of application of Montreal Cognitive Assessment Scale to assessment of cognition in Parkinson's disease

作　　者：李少华[1,2] 张玉虎[1] 聂坤[1] 赵洁皓[1] 王丽敏[1] 王丽娟[1] 

机构地区：[1]广东省医学科学院 广东省人民医院神经内科 广东省神经科学研究所,广州510080 [2]南方医科大学

出　　处：《中华老年心脑血管病杂志》2010年第9期771-773,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(30870863,30801219);广东省自然科学基金(7001198,06300979);广东省医学科研基金(A2009038)

摘　　要：目的探讨蒙特利尔认知评估量表(MoCA)中文北京版用于帕金森病(PD)认知评估的可行性。方法分别用MoCA和简易智能状态检查量表(MMSE)对78例PD患者进行认知功能评估,分析评估结果。结果 PD患者MoCA与MMSE评分分别为(23.7±3.8)分和(27.7±2.3)分,MoCA评分明显低于MMSE,差异有统计学意义(P<0.05);Pearson相关分析显示,MoCA与MMSE总分显著相关(r=0.89,P<0.05)。在MMSE评定认知功能正常的患者中有50.7%MoCA评定有认知障碍。19例MMSE评分为30分患者的平均MoCA评分为(27.1±1.63)分,其中18例MoCA评分<30分。MoCA延迟回忆下降发生率明显高于MMSE记忆和回忆能力下降发生率。结论 MoCA与MMSE总分上有较好的相关性,MoCA用作PD认知筛查时敏感性高于MMSE,较MMSE更适合用于PD患者的认知障碍筛查。Objective To investigate the feasibility of application of Montreal Cognitive Assessment Scale（MoCA） Chinese version to the assessment of global cognition in Parkinson＇s disease （PD）. Methods Seventy-eight PD patients were included. Their cognitive functions were assessed with MoCA and Mini-Mental State Examination（MMSE） and the results were analyzed and compared. Results Mean MoCA and MMSE scores standard deviation were 23.7±3.8 and 27. 7±2.3 respectively. MoCA scores were significantly lower than MMSE scores （P 〈 0.05） and there was a high correlation between the MMSE and the MoCA sores by Pearson correlation tests （r = 0.89,P 〈 0.05）. 50.7% of the PD patients with ＇normal＇ global cognition according to MMSE had cognitive impairment by MoCA. Nineteen cases with MMSE score 30 points had an average score（27.1 ± 1.63） points by MoCA,including 18 cases with MoCA score〈30 points. Conclusion MoCA and MMSE scores have a good correlation. The MoCA has higher sensitivity than the MMSE for cognitive assessment in PD patients. The MoCA is more suitable than the MMSE as a cognitive screening tool for PD patients.

关 键 词：认知障碍 帕金森病 记忆障碍 回忆 蒙特利尔认知评估量表 简易智能状态检查量表 

分 类 号：R742.5[医药卫生—神经病学与精神病学]