帕金森病非运动症状的临床分析  

Clinical analysis on non-motor symptoms of Parkinson's disease

作　　者：万华瑛[1] 冯涛[1] 张璇[1] 刘萍[1] 陈彪[2] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,100050 [2]首都医科大学宣武医院神经内科

出　　处：《中华老年心脑血管病杂志》2010年第9期817-819,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金："十一五"国家高技术研究发展计划(2006AA02A408)

摘　　要：目的通过对帕金森病患者非运动症状发生率进行分析,探讨非运动症状的临床特征。方法采用"帕金森病非运动症状筛查量表"对146例帕金森病患者的非运动症状发生率进行排序,并结合临床类型、Hoehn-Yahr分期等因素对非运动症状进行分析。结果帕金森病非运动症状的总发生率为98.6%,其中便秘的发生率最高为82.9%,其次为睡眠障碍(66.4%)、小便障碍(63.7%)、记忆困难(57.5%)、性生活障碍(50.7%)等。非运动症状发生率随Hoehn-Yahr分期的增加而增加,差异有统计学意义(P<0.01)。结论自主神经功能障碍是帕金森病最常见的非运动症状。Hoehn-Yahr分期与非运动症状发生率明显相关。Objective To analyze the non-motor symptoms of Parkinson＇s disease（PD） in order to explore their clinical features. Methods ＂Questionnaire of non-motor symptoms in patients with PD＂was used in 146 cases of PD. Non-motor symptom incidence, clinical type, Hoehn-Yahr grade and other possible influential factors were analyzed. Results The total rate of non-motor symptoms of PD was 98.6% ,the highest was constipation（82.9%）,followed by sleep disorders,urination disturbance, memory difficulty, sexual life disturbance, etc. The incidence of non-motor symp- toms increased with increase in Hoehn-Yahr grade significantly. Conclusion Parasympathetic system symptoms are the commonest non-motor symptoms. Hoehn-Yahr grade is significantly cerrelated to the incidence of non-motor symptoms.

关 键 词：帕金森病 睡眠障碍 记忆障碍 便秘 自主神经系统疾病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]