葛根素对去卵巢大鼠骨密度和骨强度的改善  

EFFECTS OF PUERARIN ON OSTEOPOROSIS OF OVARIECTOMIZED RATS

作　　者：黄彤[1,2] 金邦荃[3] 孙桂菊[4] 杜先锋[1] 宛晓春[1] 

机构地区：[1]安徽农业大学农业部茶叶生物化学与生物技术重点开放实验室,合肥230036 [2]四川宜宾学院生命科学与食品工程学院 [3]南京师范大学金陵女子学院食品科学与营养系 [4]东南大学公共卫生学院营养与食品卫生学系

出　　处：《现代预防医学》2010年第20期3894-3896,共3页Modern Preventive Medicine

基　　金：安徽省"十五"重大科技专项课题"葛根种植及深加工综合利用研究"(01803025)

摘　　要：[目的]研究葛根素对去卵巢大鼠骨密度和骨强度的影响,探讨葛根素对雌激素缺乏引起的骨质疏松的治疗作用。[方法]3月龄清洁级SD大鼠,背驮式切除双侧卵巢后每天灌胃葛根素(P)5mg/kg,10mg/kg和20mg/kg,并设假手术组(Sham),模型组(OVX)和己烯雌酚阳性对照组(E)(每天灌胃己烯雌酚100μg/kg)。3个月后处死动物,测定大鼠胫骨矿物质含量、骨钙含量、股骨密度及肱骨生物力学性能。[结果]葛根素各组的胫骨骨矿含量、骨钙含量、股骨密度和肱骨所能承受的最大压力明显高于模型组,说明服用葛根素后大鼠不仅骨量得到增加,而且骨强度有所增强。[结论]葛根素对去卵巢大鼠的骨密度和骨强度有较好的改善作用,这种作用可能和它的雌激素活性有关。[Objective] To observe the effects of Puerarin on osteoporosis of ovariectomized rats.[Methods] Sixty three-month-old female SD rats were ovariectomized bilateral under anesthesia.Except for the Sham and OVX group,the other animals were orally administrated with 5mg/kg,10mg/kg and 20mg/kg Puerarin（P） or diethylstilbestrol（100μg/kg） respectively for 3 months.The tibial BMC,Ca content of tibia,femoral BMD and humerus biodynamics were detected.[Results] The tibial BMC,Ca content of tibia,femoral BMD and the humeral in the Puerarin groups beared more pressure than those in OVX group（P﹤0.05,P﹤0.01）,which indicated the Puerarin can not only enhance the bone mass,but also improve the bone strength.[Conclusion] Puerarin has enhancive effects on osteoporosis induced by ovariectomy.The effects of Puerarin may be attribute to its estrogen action.

关 键 词：葛根素 去卵巢 骨密度 骨强度 雌激素活性 

分 类 号：R977.1[医药卫生—药品]