胃癌不同部位可根治性手术的生存率分析  

SURVIVAL ANALYSIS OF RADICAL SURGERY ON THE GASTRIC CANCER

作　　者：艾孜买提.热合木吐拉[1] 艾克热木.玉素甫 帕尔哈提.沙依木 派祖拉.马木提 王海江[1] 

机构地区：[1]新疆医科大学附属肿瘤医院,乌鲁木齐830011

出　　处：《现代预防医学》2010年第20期3957-3960,共4页Modern Preventive Medicine

摘　　要：[目的]探讨不同部位肿瘤的胃癌患者与生存因素之间的关系。[方法]收集2003年6月～2009年12月经新疆医科大学附属肿瘤医院收治并行手术治疗的胃癌病例176例,对其一般情况(包括年龄、性别、民族),手术治疗方式,肿瘤部位,组织学类型,浸润深度,淋巴结转移情况,pTNM分期及Borrmann分型等指标与不同部位胃癌患者的预后意义行COX回归分析,分析其对不同部位胃癌患者预后的影响。[结果]全组总的1年生存率为86.93%、3年生存率为61.93%、5年总生存率为45.45%。单因素COX回归分析结果表明性别(P=0.011),年龄(P=0.021)、切胃方式(P=0.000)、肿瘤分化程度均(P=0.001)与肿瘤部位之间有统计学意义(P﹤0.05)。而族别、根治手术方式,肿瘤标记物CEA、Borrmann分型、TNM分期、浸润深度、淋巴结转移情况、组织学类型等因素与不同部位胃癌预后之间没有统计学意义(P﹥0.05)。多因素COX回归分析结果表明切胃方式、CEA、Borrmann分型,TNM分期,淋巴结转移,肿瘤部位等因素与不同部位胃癌患者生存率之间有统计学意义。[结论]性别、年龄、切胃方式、肿瘤分化程度均与胃癌的发生部位之间有统计学意义(P﹤0.05)。族别、根治手术方式,肿瘤标记物CEA、Borrmann分型、TNM分期、浸润深度、淋巴结转移情况、组织学类型等因素与不同部位胃癌预后之间没有统计学意义(P﹥0.05)。[Objective] To identify independent factors after gastric resection on patients with tumor location.[Methods] There were 176 cases with postoperative gastric cancer collected from Jan.2003 to Dec.2009 in the tumor Hospital of Xinjiang Medical Universit,the data concerning common state of patients（include age gender and nationality）,surgical treatment,tumor site,histological subtypes,depth of invasion,lymph node metastasis,pTNM stage,Borrmann types and survival rate were enrolled in this retrospectively analyzed study.Life Table,Kaplan-Meier and Cox regression analysis were used to evaluate the prognostic factors significance of gastric cancer.[Results] Among 176 patients,the overall survival rate for 1,3 and 5 years were 86.93%,61.93% and 45.45%,respectively.The result of univariate analysis indicated that operation type,sex,age tumor site and histological subtypes were found to be significantly associated with the prognosis.Whereas depth of invasion,pTNM stage and lymph node metastasis as well as tumor location had no significant association with the prognosis.The cox multivariate analysis further showed that the operation type,histological subtypes,depth of invasion,lymph node metastasis and pTNM stage were the major independent prognostic factors.[Conclusion] Operation type,histological subtypes,depth of invasion,pTNM stage and metastasis lymphnode were independent prognostic factors in patients with postoperative gastric cancer in our study.But There is no significant difference among sex,age,tumor location and survival.

关 键 词：胃癌 预后 COX分析 手术 

分 类 号：R735.2[医药卫生—肿瘤]