中国及荷兰人群vWF基因内含子40多态性分析  

Human vWF Gene Intron 40 Polymorphism in Chinese and Dutch Population

作　　者：郭大玮[1] 郎海丽[1] 徐晓莉[1] 

机构地区：[1]山西医科大学法医系

出　　处：《遗传》1999年第3期16-19,共4页Hereditas（Beijing)

基　　金：山西省回国人员基金;山西省教委青年学科带头人培养对象基金

摘　　要：本文调查了中国汉族及荷兰高加索群体中人类ｖＷＦ基因内含子４０ｎｔ３１／２２１５～２３８０区域ＨＵＭＦＡ３１（Ｃ）遗传多态性的基因频率及基因型频率分布。并对两群体之间的分布以拟然比方法进行比较。对９个等位基因片段测序的结果表明，在ｎｔ３１／２２３４～２２６５区域也有变异存在。提示该座位当被测等位基因ＤＮＡ片段长度相同时，仍可能存在遗传差异。The allele frequencies and phenotype distribution of human vWF gene intron 40 in the region of nt 31/2 215～2 380 (HUMFA 31(C)) were investigated in the population of the Netherlands and China. The data between two populations were compared by likelihood ratio test. Nine alleles were sequenced and the polymorphism of region of nt 31/2 234～2 265 was revealed.

关 键 词：VWF基因 遗传多态性 基因频率 DNA序列 

分 类 号：Q986[生物学—人类学] Q346.5