新型吲哚并[1,2-b]吲哒唑三氟甲磺酸盐衍生物的合成及其抗肿瘤活性  

Synthesis of Novel Indolo[1,2-b] indazole Triflate Derivativesand Their Anticancer Activities

作　　者：李秋莲[1] 池建文[1] 朱永明[1] 

机构地区：[1]苏州大学医学部药学院,江苏苏州215123

出　　处：《合成化学》2010年第5期602-604,621,共4页Chinese Journal of Synthetic Chemistry

基　　金：江苏省自然科学基金资助项目(BK2006048)

摘　　要：吲哚并[1,2-b]吲哒唑类化合物与三氟甲磺酸甲酯成盐,再与对二甲氨基苯甲醛偶联合成了3个新型吲哚并[1,2-b]吲哒唑三氟甲磺酸盐衍生物(3a^3 c),其结构经NMR和IR表征。用MTT法检测了3对白血病细胞HL-60和K562的抗肿瘤活性,结果显示3具有良好的体外抗肿瘤活性。Three novel indolo[1,2-b] indazole triflate derivatives（3a^3c） were synthesized by salification of indoloindazole derivatives with methyl trifluoromethanesulfonate,then coupling with p-dimethylaminobenzaldehyde.The structures were characterized by NMR and IR.The anticancer activities of 3 against cancer cell lines HL-60 and K562 were tested by the MTT method in vitro.The results showed that 3 exhibited potent anticancer activities.

关 键 词：吲哚并[1 2-b]吲哒唑 合成 抗肿瘤活性 

分 类 号：O626[理学—有机化学] R914.5[理学—化学]