癌痛消颗粒对小鼠急性毒性实验研究  

Experimental Study on Acute Toxicity of Drug Aitongxiao Granule

作　　者：韦艾凌[1] 官志杰[1] 邱子津[1] 李国政[1] 李红霞[1] 

机构地区：[1]广西中医学院第一附属医院,广西南宁530023

出　　处：《辽宁中医药大学学报》2010年第10期5-7,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：广西科技攻关项目(桂科攻0718002-2-15);研究生导师课题(Y2007030)

摘　　要：以癌痛消颗粒的水溶剂对小鼠灌胃,观察小鼠死亡情况及相关指标的变化情况来评价其安全性。半数致死量实验以不同浓度的药液及饱和药液对小鼠灌胃,观察2周未见小鼠死亡,无法测出半数致死量。进行最大耐受量实验,以饱和溶液1天内对小鼠灌胃3次。灌胃后小鼠心、肝、脾、肺、肾、睾丸/卵巢等与体重的比值较对照组差异无显著性意义(均P>0.05);血常规及肝肾功能指标值差异亦无显著性意义(均P>0.05)。灌入药物总量相当于7.95g生药,折合成人临床日用量为164.6倍,符合临床应用及推广要求,对长期毒性实验剂量的设计和药物Ⅰ期临床实验起始剂量的选择具有重要参考价值。To measure the LD50 and to observe the number of deaths and the parameters of the experimental animals when Aitongxiao Granule is taken orally into the mic.No animal deaths.The LD50 can not measure up.To measure the maximum tolerance the highest concentration and largest amount was given to the mice by stomach feeding.All mice healthily survived during the period of test,and no obvious symptoms were observed.The maximum tolerance dose was as 164.6 times as that used in clinic.The outcome could offering important evidence for clinical safe dose.

关 键 词：癌痛消颗粒 急性毒性实验 

分 类 号：R73[医药卫生—肿瘤]