左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的疗效比较  

Levofloxacin Triple Therapy and Amoxicillin Triple Therapy in Treatment of Peptic Ulcer:Comparison of Efficacy

作　　者：陈燕萍[1] 王群英[1] 滕卫军[1] 郑小娟[1] 

机构地区：[1]金华市中心医院消化科,浙江金华321000

出　　处：《中国现代医生》2010年第28期111-112,共2页China Modern Doctor

摘　　要：目的比较左氧氟沙星三联疗法与阿莫西林三联疗法分别治疗消化性溃疡的疗效。方法 200例消化性溃疡患者分为观察组和对照组。观察组:左氧氟沙星+奥美拉唑+呋喃唑酮;对照组:阿莫西林+奥美拉唑+呋喃唑酮。结果观察组总有效率为91.00%,与对照组总有效率86.00%比较,差异不显著(P>0.05);两组的不良反应比较,差异也不显著(P>0.05)。观察组每日用费少于对照组每日用费。阿莫西林的耐药菌株是11.5%,但这些菌株对左氧氟沙星均敏感。结论左氧氟沙星、奥美拉唑与呋喃唑酮治疗消化性溃疡患者疗效佳、安全,也相对实惠。在阿莫西林耐药的情况下,消化性溃疡患者可选择左氧氟沙星抗菌治疗。Objective To compare the efficacy of levofloxacin triple therapy and amoxicillin triple therapy in the treatment of peptic ulcer. Methods We divided 200 eases of peptic ulcer into observation group and control group. The observation group was treated by using three drugs combined therapy of levofloxacin ＋ omeprazole ＋ furazolidone and the control group was treated by using amoxicillin ＋ omeprazole ＋ furazolidone. Results The total effective rate of the observation group was 91.00%, and that of the control group was 86.00%, and there were no significant differences in the total effective rate and the adverse reaction between the two groups（P〉0.05 ）. The daily cost of the observation group was less than that of the control group. Amoxicillin resistant strains showed 11.5%, but these strains were sensitive to levofloxacin. Conclusion Levofloxacin ＋ omeprazole ＋ furazolidone treatment of peptic ulcer shows good efficacy, safety, and relatively low cost. In the condition of amoxicillin resistance, levofloxacin can be selected in the treatment of peptic ulcer.

关 键 词：三联疗法 消化性溃疡 耐药 左氧氟沙星 阿莫西林 呋喃唑酮 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统]