进口长春瑞滨与国产长春新碱治疗急性淋巴细胞白血病的疗效比较  

Efficacy Comparison Between Vinorelbine and Vincristine in Treatment of Acute Lymphoblastic Leukemia

作　　者：方遒[1] 张慧英[1] 

机构地区：[1]湖州市中心医院血液内科,浙江湖州313000

出　　处：《中国现代医生》2010年第28期123-124,共2页China Modern Doctor

摘　　要：目的比较"吡柔比星+左旋门冬酰胺酶+强的松+硫酸长春新碱"与"吡柔比星+左旋门冬酰胺酶+强的松+重酒石酸长春瑞滨注射液"分别诱导化疗ALL患者的疗效。方法 40例ALL患者,分成观察组和对照组。对照组:"吡柔比星+左旋门冬酰胺酶+强的松+重酒石酸长春瑞滨注射液"诱导化疗;观察组:"吡柔比星+左旋门冬酰胺酶+强的松+硫酸长春新碱"诱导化疗。结果观察组和对照组的CR率、PR率与NR率,差异无统计学意义(P>0.05),见表1。造血系统毒副作用、非血液学毒性反应及继发感染发生率等,差异均无统计学意义(P>0.05),见表2。国产药长春新碱要比进口药长春瑞滨实惠。结论吡柔比星、左旋门冬酰胺酶和强的松加用国产药注射用硫酸长春新碱诱导化疗ALL患者不但疗效佳,而且也经济实惠,建议临床进一步推广。Objective To compare the efficacy of ＂THP ＋ L-asparaginase ＋ prednisone ＋ vincristine sulfate＂ with ＂THP ＋ L-asparaginase ＋ prednisone ＋ vinorelbine bitartrate injection for induction chemotherapy in acute lymphoblastic leukemia（ALL）. Methods Forty cases of ALL were divided into observation group and control group,and the control group was treated by using ＂THP ＋ L-asparaginase ＋ prednisone ＋ vinorelbine bitartrate injection＂ for induction chemotherapy,and the observation group was treated by using ＂THP ＋ L-asparaginase ＋ prednisone ＋ vincristine sulfate＂ for induction chemotherapy. Results There were no significant differences in the CR rate, PR rate and NR rate （P〉0.05,Table 1 ） as well as hematopoietic system side effects, non-hematologic toxicity and incidence of secondary infection （P〉0.05, Table 2） between the two groups. Vincristine showed less cost compared with vinorelbine. Conclusion The method of THP, L-asparaginase, prednisone, and domestic drug vincristine sulfate injection for induction chemotherapy in ALL is both effective and affordable and the clinical further is proposed.

关 键 词：急性淋巴细胞白血病 注射用硫酸长春新碱 重酒石酸长春瑞滨注射液 

分 类 号：R730.53[医药卫生—肿瘤] R733.71[医药卫生—临床医学]