p53和c-myc基因在肝癌和肝硬变细胞中的表达  

Expression of p53 gene and cmyc gene in liver neoplasms and liver cirrhosises.

作　　者：单长民[1] 崔秀珍[1] 刘同慎[1] 

机构地区：[1]山东省滨州医学院生物教研室

出　　处：《中国优生与遗传杂志》1999年第3期25-26,共2页Chinese Journal of Birth Health & Heredity

摘　　要：本实验用免疫组化技术ＡＢＣ法，测定了肝癌和肝硬变细胞中的ｐ５３和ｃ－ｍｙｃ蛋白。结果表明：肝癌组的突变ｐ５３和ｃ－ｍｙｃ基因表达均显著增高（Ｐ＜０．０１），而肝硬变组中ｐ５３和ｃ－ｍｙｃ的表达与正常组无显著差异，肝硬变组的ｃ－ｍｙｃ表达明显低于肝癌组。以上结果提示，ｐ５３基因发生突变、失活以及ｃ－ｍｙｃ基因激活，导致肝癌的发生。In order to understand the occurrence mechanism of liver neoplasms,we detected the p53 protein and cmyc protein in the cell of liver neoplasms and liver eirrhosises.The results showex:in the cancer group the expression of mutant genes and cmyc genes are markedly increased (P<0.01),but their expressions of liver cirrhosises are not significantly higher than those of normal contrals,the expression of cmyc genes in the cirrhosises is clearly lower than the in the cancer group.The upper results suggest that mutation of p53 genes,inactivation of the genes and activation of cmyc genes lead to the occurrence of liver neoplasms.

关 键 词：肝癌 肝硬变 P53基因 C-MYC蛋白 

分 类 号：R735.702[医药卫生—肿瘤] R575.202[医药卫生—临床医学]