治疗剂量的^(131)Ⅰ对甲亢患者淋巴细胞染色体影响的研究  

Study on SCE frequency and chromosome abnormal rate of Graves' disease patients' perpheral blood lymphocytes befor and after treating withI.

作　　者：代军 胡绍 

机构地区：[1]武汉市第二医院遗传室

出　　处：《中国优生与遗传杂志》1999年第3期51-51,共1页Chinese Journal of Birth Health & Heredity

摘　　要：本文随机选择６０例服１３１Ⅰ治疗的甲亢（甲状腺机能亢进）患者对其服１３１Ⅰ前１天、服１３１Ⅰ后第６天、２个月和６个月分别进行ＳＣＥ频率和染色体畸变率的检测。结果是服１３１Ⅰ前１天、服１３１Ⅰ后第６天、２个月和６个月患者的淋巴细胞ＳＣＥ频率和染色体畸变率分别为：４４５±０７２，０２８±００９；７６１±１２４，０７７±０１８；６９４±１１８，０３７±０１３；４５３±０６２，０３４±０１１。经过统计分析（ｔ检验）服１３１Ⅰ前１天和服１３１Ⅰ后第６天ＳＣＥ频率和染色体畸变率均有非常显著性差异，服１３１Ⅰ２个月后ＳＣＥ频率和染色体畸变率有所下降，与服１３１Ⅰ前一天比较ＳＣＥ频率仍具有显著性差异，染色体畸变率无显著性差异；服１３１Ⅰ６个月后ＳＣＥ频率和染色体畸变率恢复到服１３１Ⅰ前一天的水平，两者之间均无显著性差异。因此我们认为治疗剂量（平均为２２２ＭＢｑ）的１３１Ⅰ对甲亢患者的染色体具有一定的损伤，但这种损伤可在６个月内得到恢复。The sixty case Graves' disease patients were choose freely in this study.It was analysised that SCE frequency and chromosome abnormal rate (CAR) of these patients' perpheral blood lymphocytes in the first day before taking 131 I,the sixth day and the second month and the sixth month abter taking 131 I.We found.1.SCE pequency(7.61±1.24) and CAR(0.77±0.18) of the sixth day after taking 131 I is remarkably higher than SCE frequency (4.45±0.72) and CAR(0.28±0.09) of the first day before taking 131 I.There is remarkably difference between two of them.2.SCE frequency and CAR in the sixth month after taking 131 I are respectivly 4.53±0.62 and 0.34±0.11.They restored to level of the first day before taking 131 I. There is no remarkably difference between two of them.The conclusion above point out that 131 I of treatment quantity(even 222 MBq) gives rise to some harm to chromosome of Graves' disease patients, but the harm can be restored in the six months.

关 键 词：^131I 淋巴细胞 SCE 染色体畸变 甲状腺机能亢进 

分 类 号：R581.105[医药卫生—内分泌]