新疆塔什库尔干地区高原新生儿染色体畸变观察  

Observation on chromosome aberration of neonate at high altitude.

作　　者：谭德银 戴鑫琦[1,2,3] 余良宽 赵红艳[1,2,3] 王德堂 潘钦[1,2,3] 陈远军 

机构地区：[1]新疆疏勒县解放军第十二中心医院 [2]中国人民解放军第四军医大学西京医院 [3]中国人民解放军第三六九二二部队卫生队

出　　处：《中国优生与遗传杂志》1999年第3期63-64,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的：了解高原低氧分压对新生儿染色体畸变的影响。方法：收集新生儿脐带血（高原１６例，对照组５０例）常规培养、制片、Ｇ式显带、计数观察。结果：（１）高原组１６例新生儿中，染色体结构发生改变１０例，占６２５％，明显高于对照组１６０％（８／５０）（Ｐ＜０．０１）。（２）高原组新生儿染色体计数观察１５９４个，发生畸变８３个，占５２０７％；对照组共计数观察５００２个，发生畸变９４个，占１８７９％，两组比较有极高度显著性差异（Ｐ＜０．０１）。（３）高原组新生儿染色体结构异常占２１３３％（３４／１５９４），其中内复制６个，双微体１４个，碎片断１０个，着丝粒爆开１个，断裂或增加３个，明显高于对照组０４２％（２１／５００２）（Ｐ＜０．０１）。（４）高原新生儿染色体数目异常占３０７％（４９／１５９４），明显高于对照组１４５９％（７３／５００２）（Ｐ＜０．０１）。结论：高原新生儿染色体畸变率增加可能与高原低氧分压有关。Objective:To study the impact of hypoxia on neonatal chromosome aberration in high altitude.Methods:Culture of routine and counting,observating on 66 cases of neonatal cordblood(16 cases in high altitude,20 cases in Kashigar and the other 30 in Xian).Results:(1) The changes chromosome structure occured rate were 62.5%(10/16) of the neonate in high altitude,significantly higher than contrast 16.0%(8/50)(P<0.01).(2)The chromosome of the 16 cultures counted 1594 and 83 of them aberrated,with an aberration rate of 5.207%,significantly higher than contrast were 1.879%(94/5002)(P<0.01).(3)34 of the 1594 chromosomes have abnomal structure at high altitude rating 2.133%.Among them there are 6 endoreduplications,14 minute bodies,10 fragment,1 centric burst and 3 part deletion and insertion,also higher than that of contrast 0.42%(21/5002)(P<0.01).(4)The changes of chromosome's number were 3.07(49/1594) at high altitude,significantly higher than that contrast 1.459%(73/5002)(P<0.01).Conclusions:The higher chromosome aberration rate of high altitude neonatal may be caused by hypoxia.

关 键 词：高原 新生儿 染色体畸变 低氧分压 

分 类 号：R596.102[医药卫生—内科学] R363.125[医药卫生—临床医学]