氟尿嘧啶栓联合放疗治疗老年局部晚期直肠癌的临床观察  

Fluorouracil suppository and concurrent radiotherapy in elderly local advanced rectal cancer

作　　者：李英[1] 代红伟[1] 孙玉新[1] 巩合义[2] 周涛[2] 沈太春[1] 

机构地区：[1]山东省聊城市第二人民医院放疗科,252600 [2]山东省肿瘤医院放疗科

出　　处：《中国临床实用医学》2010年第10期43-45,共3页China Clinical Practical Medicine

摘　　要：目的观察氟尿嘧啶栓联合放疗治疗老年局部晚期不可手术直肠癌的疗效和不良反应。方法46例经病理证实的老年局部晚期不可手术的直肠癌患者接受氟尿嘧啶栓塞肛，200mg／粒，20：／d，连用10d。24d为一周期，共用2个周期。同期接受盆腔三维适形放疗，46～50Gy／23～25F，后缩野至肿瘤区继续推量至64—66Gy／32～33F，如有残留病灶则行腔内放疗15～20Gy。结果CR18例（39．1％），PR23例（50．0％），SD5例（10．9％），总有效率（CR＋PR）89．1％，中位生存时间21．6个月，1、2年生存率分别为87．4％、71．9％。治疗相关毒副作用主要是腹泻和中性粒细胞减少，经对症处理患者均能耐受。结论氟尿嘧啶栓联合放疗治疗老年局部晚期不可手术的直肠癌安全、有效，值得临床进一步研究。Objective To observe the effect and toxicity of fluorouracil suppository and concurrent radiotherapy in elderly local advanced rectal cancer. Methods Forty-six elderly patients with ocal advanced rectal cancer were treated with 200 mg fiuorouracil suppository by rectum, twice a day, for 10 days, a 24-dat cases of treatment, two cases of the treatment and combination with three dimensional-conformal radiotherapy（ for46 -50 Gy/23 - 25F and was boosted to the tumor 16 ~ 18Gy/2 weeks,2Gy/fraction,5 days/week）. Intra-rectal cavity radiotherapy with 15 -20 Gy for the residual lesion. Results The overall response rate was 89. 1%, with CR 18 cases （39.1% ）, PR 23 cases （50. 0% ） , SD 5cases （ 10. 9% ）. Median survival time, the 1,2a survival rate were 21.6 months, 87.4% ,71.9% respectively. Treatment-related toxicity mainly showed at diarrhea and neutrocytopenia. Conclusion Fluorouracil suppository and concurrent radiotherapy in elderly local advanced rectal cancer is salty,effective and valuable clincial study.

关 键 词：局部晚期 直肠癌 氟尿嘧啶栓 放疗 

分 类 号：R735[医药卫生—肿瘤]