牛痘疫苗接种家兔炎症皮肤提取物治疗三叉神经痛射频热凝术后残余神经症状的疗效观察  

EFFECT OF NEUROTROPIN ON THE REMNANT SYMPTOMS OF TRIGEMINAL NEURALGIA AFTER PERCUTANEOUS RADIOFREQUENCY THERMORHIZOTOMY

作　　者：江兴华[1] 王亚平[1] 邹定权[1] 肖锋[1] 徐军美 

机构地区：[1]中南大学湘雅二医院麻醉科,长沙410011

出　　处：《中国疼痛医学杂志》2010年第5期266-268,共3页Chinese Journal of Pain Medicine

摘　　要：目的:观察牛痘疫苗接种家兔炎症皮肤提取物(神经妥乐平)对原发性三叉神经痛射频温控热凝术后面部残余神经症状的疗效。方法:应用随机单盲对照的方法,选择原发性三叉神经痛射频温控热凝术后面部仍残留有神经症状,视觉模拟评分(VAS)在3分以上的患者30例,分成神经妥乐平组和安慰剂组各15例。神经妥乐平组给予神经妥乐平18AGC单位+生理盐水250 ml静脉滴注,连续7 d;安慰剂组给予生理盐水250 ml静脉滴注,连续7 d。观察两组患者用药后面部疼痛和麻木感改变情况。结果:术后1、3d神经妥乐平组疼痛评分和术后7、14 d神经妥乐平组麻木感评分改善率与对照组比较差异均有显著性,神经妥乐平组患者用药后未出现不良反应。结论:神经妥乐平静脉注射可有效治疗原发性三叉神经痛射频温控热凝术后面部残留的疼痛感和麻木感。Objective： To verify the efficacy of Neurotropin on remnant symptoms after the percutaneous radiofrequency thermorhizotomy in patiens with trigeminal neuralgia.Methods： By a randomized single blind procedure,30 patients who had received percutaneous radiofrequency thermorhizotomy were divided into two groups： Neurotropin group and control group（n=15）.Neurotropin 18 AGC unit added to 250ml saline was intravenously dripped for 7 days in Neurotropin group.Normal saline was intravenously dripped in control group.The scores of pain and numbness were observed by VAS after treatment.Results： Neurotropin significantly reduced the scores of pain and numbness on 1,3,7,and 14d after treatment.There were significantly difference between the two groups.There were no obvious adverse events in Neurotropin group.Conclusion： Neurotropin is effective in treating remnant symptoms of trigeminal neuralgia after percutaneous radiofrequency thermorhizotomy,which is involved in pain and numbness.

关 键 词：原发性三叉神经痛 神经妥乐平 疼痛 麻木 

分 类 号：R745.11[医药卫生—神经病学与精神病学]