睾旁胚胎型横纹肌肉瘤5例报告并文献复习  

Paratesticular embryonal rhabdomyosarcoma:Report of 5 cases and review of the literature

作　　者：杨国胜[1] 姜海[2] 夏丹[2] 范立新[1] 刘百川[1] 钟瑞伦[1] 罗友华[1] 周沈阳[1] 

机构地区：[1]广东省第二人民医院泌尿外科,广东广州510317 [2]浙江大学医学院附属第一医院泌尿外科,浙江杭州310003

出　　处：《中华男科学杂志》2010年第9期840-843,共4页National Journal of Andrology

摘　　要：目的:提高睾旁胚胎型横纹肌肉瘤的诊治水平。方法:回顾性分析5例睾旁胚胎型横纹肌肉瘤患者的临床资料,结合文献复习进行讨论。结果:5例患者中精索胚胎型横纹肌肉瘤2例、附睾胚胎型横纹肌肉瘤2例、鞘膜横纹肌肉瘤1例,临床病理分期Ⅰ期2例,Ⅱ期1例,Ⅳ期2例。5例患者最终均行根治性睾丸切除术及肿块完整切除术。1例Ⅰb期和1例Ⅱ期患者术后采用异环磷酰胺、长春新碱、足叶乙甙、丝裂霉素、顺铂化疗并配合局部放疗,余3例未行进一步治疗。2例Ⅰ期、1例Ⅱ期患者随访28、18、12个月未见复发和转移,1例Ⅳ期患者随访6个月后死于多发转移,1例Ⅳ期随访6个月未见复发和转移,后失访。结论:早期诊断,根治性手术并辅助化疗、放疗是治疗睾旁胚胎型横纹肌肉瘤的有效手段。Objective：To improve the diagnosis and treatment of paratesticular embryonal rhabdomyosarcoma（PER）.Methods：We retrospectively studied the clinical data of 5 cases of PER treated from 1997 to 2009 and reviewed the relevant literature,focusing on its clinical manifestations,diagnosis and treatment.Results：The 5 cases of PER,2 involving the spermatic cord,2 the testis and 1 the tunica vaginalis,were all treated by radical orchiectomy.Pathologically,2 cases were classified as stage I,1 as stage Ⅱ and 2 as stage Ⅳ.Postoperatively,2 of the patients received chemotherapy and the other 3 refused adjunctive therapy.The patients were followed up for 6,12,18 and 28 months,respectively.Four of them remained free from relapse and metastasis,and 1 stage Ⅳ patient died of multiple metastasis at 6 months.Conclusion：Early diagnosis,radical orchiectomy and adjunctive chemo-or radio-therapy are effective means to the treatment of PER.

关 键 词：阴囊 横纹肌肉瘤 根治性手术 

分 类 号：R737.21[医药卫生—肿瘤]